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Table 5 Coefficients of all diagnostic models using either only expression values, protein abundance values, or both types of values in combination (65 controls vs. 224 EOC samples)

From: A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

Genes/Proteins

Coefficients (L1 and L2 penalized regression)

L1 7 Genes

L2 13 Genes

L1 4 Proteins

L2 6 Proteins

L1 5 Genes 5 Proteins

L2 13 Genes 6 Proteins

105743

0.02

0.63

   

0.26

109227

 

0.05

   

−0.01

110071

0.17

0.26

   

0.16

228089

0.91

0.99

  

0.63

0.70

713562

0.34

0.34

  

0.22

0.29

115368

 

−0.18

   

0.36

119290

 

0.28

   

0.34

142487

 

0.15

   

0.12

157342

0.36

0.64

  

0.35

0.55

161567

 

−0.56

   

−0.27

162222

−1.34

−1.34

  

−1.58

−1.30

182018

 

−0.38

   

−0.09

205406

−0.83

−1.05

  

−0.54

−0.87

log2 MIF

   

0.09

−0.05

−0.24

log2 prolactin

  

0.67

0.62

0.47

0.53

log2 CA125

  

0.71

0.67

0.33

0.39

log2 leptin

  

−0.32

−0.35

−0.55

−0.59

log2 osteopondin

   

0.05

 

−0.02

log2 IGF2

  

−0.31

−0.35

−0.47

−0.51

Intercept

3.93

4.90

−2.71

−2.77

4.91

7.31