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Table 3 Gene names and functions of the 13 genes with mean log 2 expression fold changes (A) and six proteins with mean log 2 abundance values in controls, FIGO I/II patients, and FIGO III/IV patients (B)

From: A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer - a study of the OVCAD consortium

A)

ProbeID

Gene symbol

Gene name

Function

FIGO I/IIa

FIGO III/IV

JAK STAT

Inflammatory response

115368

AP2A1

adaptor-related protein complex 2, alpha 1 subunit

Clathrin coat assembly

Down. FCb: -0.75

Down FC: -0.82

  

142487

B4GALT1

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypept. 1

Galactosyltransferase

Down (FC: -0.81)

Down (FC: -0.59)

 

+

157342

C1orf63

chromosome 1 ORF 63

Unknown

n.s. FC: +0.003

n.s. FC: +0.19

  

110071

CCR2

chemokine (C-C motif) receptor 2

Chemokine receptor

n.s. FC: +0.72

Up FC: +0.96

+

+

119290

CFP

complement factor properdin

Alternative pathway for complement activation

Down FC: -1.06

Down FC: -1.03

 

+

105743

DIS3

DIS3 mitotic control homolog (S. cerevisiae)

RNase, part of the exosome complex

n.s. (FC: +0.01)

Up (FC: +0.27)

  

228089

NEAT1

non-protein coding RNA 84

Non-coding RNA

n.s. FC: -0.01

n.s. FC: +0.26

  

182018

NOXA1

NADPH oxidase activator 1

Activates NADPH oxidases

n.s. FC: -0.52

Down FC: -0.60

  

205406

OSM

oncostatin M

IL-6 family cytokine

Down FC: -2.62

Down FC: -2.65

+

 

161567

PAPOLG

poly(A) polymerase gamma

Poly(A) polymerase

n.s. FC: -0.28

n.s. FC: -0.34

  

162222

PRIC285

peroxisomal proliferator-activated receptor A interacting complex 285

Nuclear transcriptional coactivator for several nuclear receptors

Down FC: -2.24

Down FC: -2.33

  

109227

ZNF419

zinc finger protein 419

Zinc finger protein

n.s. (FC: -.19)

n.s. (FC: +0.21)

  

713562

BC037918

(no ORF in transcript BC037918)

Non-coding RNA

n.s. FC: +0.06

n.s. FC: +0.52

  

B)

Protein

Control

FIGO I/II

corr. p c

FIGO III/IV

corr. p c

  

log2 MIF

8.86

9.67

0.028

9.25

0.040

  

log2 prolactin

4.70

6.26

<0.001

6.79

<0.001

  

log2 CA125

3.83

7.24

<0.001

8.52

<0.001

  

log2 leptin

3.92

2.78

0.033

2.15

<0.001

  

log2 osteopontin

3.84

4.59

0.067

5.08

<0.001

  

log2 IGF2

10.94

9.10

<0.001

9.16

<0.001

  
  1. aSignificant down- or up-regulation in blood cells of EOC patients compared to healthy blood donors (t-test, corrected for multiple testing; n.s., not significant). bFC are actually log2-FC values.
  2. cCompared to control values.