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Table 2 Patient baseline characteristics by model response type

From: Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia

Response type

All patients, n

Sensitive baseline mutation,*n (%)

Insensitive baseline mutation,†n (%)

Imatinib-resistant, n (%)

Imatinib-intolerant, n (%)

Slow (monophasic)

65

21 (32.3)

18 (27.7)

58 (89.2)

7 (10.8)

Fast (biphasic)

58

18 (31.0)

2 (3.4)

42 (72.4)

16 (27.6)

  1. * Half maximal inhibitory concentration (IC50) ≤ 150 nm.
  2. † IC50 > 150 nm; Y253H, E255V/K, F359V/C.