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Table 2 Frequency of double mutants (N=6/201)

From: High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer

  Coexisting mutations   No. of cases Total no. of cases (%)
Gene and exon cDNA sequence Protein sequence
PIK3CA exon 9 c.1633G>A p.Glu545Lys 1 6 (3.0%)
KRAS exon 4 c.436G>A p.Ala146Thr
PIK3CA exon 9 c.1624G>A p.Glu542Lys 1
KRAS exon 3 c.183A>C p.Gln61His
PIK3CA exon 20 c.3139C>T p.His1047Tyr 1
KRAS exon 3 c.173_217dup p.Thr58_Met72dup
PIK3CA exon 20 c.3140A>G p. His1047Arg 1
KRAS exon 4 c.436G>A p.Ala146Thr
PIK3CA exon 20 c.3140A>G p.His1047Arg 1
BRAF exon 11 c.1412 T>C p.Val471Ala
KRAS exon 3 c.145G>A p.Glu49Lys 1
KRAS exon 4 c.436G>A p.Ala146Thr