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Table 1 Frequency of KRAS , BRAF and PIK3CA single mutants (N=47/201)

From: High resolution melting analysis of KRAS, BRAF and PIK3CA in KRASexon 2 wild-type metastatic colorectal cancer

  Mutation   No. of cases Total no. of cases (%)
Gene and exon cDNA sequence Protein sequence
KRAS exon 3 c.151_195dup p.Cys51_Ser65dup 1 10 (5.0%)
c.176_178del p.Ala59del 1
c.179G>T p.Gly60Val 1
c.181C>A p.Gln61Lys 1
c.182A>T p.Gln61Leu 3
c.182A>G p.Gln61Arg 2
c.183A>C p.Gln61His 1
KRAS exon 4 c.436G>A p.Ala146Thr 10 10 (5.0%)
BRAF exon 11 c.1397G>A p.Gly466Glu 1 1 (0.5%)
BRAF exon 15 c.1799 T>A pVal600Glu 8 9 (4.5%)
c.1808A>G p.Lys601Glu 1
PIK3CA exon 9 c.1624G>A p.Glu542Lys 5 14 (7.0%)
c.1633G>A p.Glu545Lys 5
c.1635G>T p.Glu545Asp 1
c.1636C>A p.Gln546Lys 3
PIK3CA exon 20 c.3129G>A p.Met1043Ile 1 3 (1.5%)
c.3140A>G p.His1047Arg 1
c.3140A>T p.His1047Leu 1