Table 1 Frequency of KRAS , BRAF and PIK3CA single mutants (N=47/201)
Mutation | No. of cases | Total no. of cases (%) | ||
|---|---|---|---|---|
Gene and exon | cDNA sequence | Protein sequence | ||
KRAS exon 3 | c.151_195dup | p.Cys51_Ser65dup | 1 | 10 (5.0%) |
c.176_178del | p.Ala59del | 1 | ||
c.179G>T | p.Gly60Val | 1 | ||
c.181C>A | p.Gln61Lys | 1 | ||
c.182A>T | p.Gln61Leu | 3 | ||
c.182A>G | p.Gln61Arg | 2 | ||
c.183A>C | p.Gln61His | 1 | ||
KRAS exon 4 | c.436G>A | p.Ala146Thr | 10 | 10 (5.0%) |
BRAF exon 11 | c.1397G>A | p.Gly466Glu | 1 | 1 (0.5%) |
BRAF exon 15 | c.1799 T>A | pVal600Glu | 8 | 9 (4.5%) |
c.1808A>G | p.Lys601Glu | 1 | ||
PIK3CA exon 9 | c.1624G>A | p.Glu542Lys | 5 | 14 (7.0%) |
c.1633G>A | p.Glu545Lys | 5 | ||
c.1635G>T | p.Glu545Asp | 1 | ||
c.1636C>A | p.Gln546Lys | 3 | ||
PIK3CA exon 20 | c.3129G>A | p.Met1043Ile | 1 | 3 (1.5%) |
c.3140A>G | p.His1047Arg | 1 | ||
c.3140A>T | p.His1047Leu | 1 |