Figure 2

Tumor uptake of [18F]FLT and [18F]FDG following treatment with belinostat.Mice with human ovary cancer xenograft tumors were treated with either belinostat (40 mg/kg ip twice daily Day 0–4 and 6–10) or vehicle and they were subjected to PET imaging with either [18F]FLT or [18F]FDG at baseline and Day 3, Day 6 and Day 10 after treatment start . [18F]FLT (upper panel) and [18F]FDG (lower panel) uptake measured as SUVmax relative to baseline (left panel) and SUVmean relative to baseline (right panel). N = 5-7 tumors/group. *) p < 0.05, **) p < 0.01, ***) p < 0.001 versus baseline in same treatment group. #) p < 0.05, ##) p < 0.01, ###) p < 0.001 treatment versus control group at same time point.