TY - JOUR AU - Jemal, A. AU - Siegel, R. AU - Ward, E. AU - Hao, Y. AU - Xu, J. AU - Thun, M. J. PY - 2009 DA - 2009// TI - Cancer statistics JO - CA Cancer J Clin VL - 59 UR - https://doi.org/10.3322/caac.20006 DO - 10.3322/caac.20006 ID - Jemal2009 ER - TY - JOUR AU - La Vecchia, C. AU - Bosetti, C. AU - Lucchini, F. AU - Bertuccio, P. AU - Negri, E. AU - Boyle, P. AU - Levi, F. PY - 2010 DA - 2010// TI - Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975 JO - Ann Oncol VL - 21 UR - https://doi.org/10.1093/annonc/mdp530 DO - 10.1093/annonc/mdp530 ID - La Vecchia2010 ER - TY - JOUR PY - 2005 DA - 2005// TI - Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials JO - Lancet VL - 365 UR - https://doi.org/10.1016/S0140-6736(05)66544-0 DO - 10.1016/S0140-6736(05)66544-0 ID - ref3 ER - TY - JOUR AU - Levine, M. N. AU - Whelan, T. PY - 2006 DA - 2006// TI - Adjuvant chemotherapy for breast cancer–30 years later JO - N Engl J Med VL - 355 UR - https://doi.org/10.1056/NEJMe068204 DO - 10.1056/NEJMe068204 ID - Levine2006 ER - TY - JOUR AU - Smith, I. AU - Chua, S. PY - 2006 DA - 2006// TI - Medical treatment of early breast cancer JO - III: chemotherapy. Bmj VL - 332 ID - Smith2006 ER - TY - JOUR AU - Doyle, J. J. AU - Neugut, A. I. AU - Jacobson, J. S. AU - Grann, V. R. AU - Hershman, D. L. PY - 2005 DA - 2005// TI - Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.02.5841 DO - 10.1200/JCO.2005.02.5841 ID - Doyle2005 ER - TY - JOUR AU - Hershman, D. AU - Neugut, A. I. AU - Jacobson, J. S. AU - Wang, J. AU - Tsai, W. Y. AU - McBride, R. AU - Bennett, C. L. AU - Grann, V. R. PY - 2007 DA - 2007// TI - Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy JO - J Natl Cancer Inst VL - 99 UR - https://doi.org/10.1093/jnci/djk028 DO - 10.1093/jnci/djk028 ID - Hershman2007 ER - TY - JOUR AU - Thompson, F. AU - Emerson, J. AU - Dalton, W. AU - Yang, J. M. AU - McGee, D. AU - Villar, H. AU - Knox, S. AU - Massey, K. AU - Weinstein, R. AU - Bhattacharyya, A. PY - 1993 DA - 1993// TI - Clonal chromosome abnormalities in human breast carcinomas. I. Twenty-eight cases with primary disease JO - Genes Chromosomes Cancer VL - 7 UR - https://doi.org/10.1002/gcc.2870070402 DO - 10.1002/gcc.2870070402 ID - Thompson1993 ER - TY - JOUR AU - Zody, M. C. AU - Garber, M. AU - Adams, D. J. AU - Sharpe, T. AU - Harrow, J. AU - Lupski, J. R. AU - Nicholson, C. AU - Searle, S. M. AU - Wilming, L. AU - Young, S. K. PY - 2006 DA - 2006// TI - DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage JO - Nature VL - 440 UR - https://doi.org/10.1038/nature04689 DO - 10.1038/nature04689 ID - Zody2006 ER - TY - JOUR AU - Botti, C. AU - Pescatore, B. AU - Mottolese, M. AU - Sciarretta, F. AU - Greco, C. AU - Di Filippo, F. AU - Gandolfo, G. M. AU - Cavaliere, F. AU - Bovani, R. AU - Varanese, A. PY - 2000 DA - 2000// TI - Incidence of chromosomes 1 and 17 aneusomy in breast cancer and adjacent tissue: an interphase cytogenetic study JO - J Am Coll Surg VL - 190 UR - https://doi.org/10.1016/S1072-7515(00)00252-0 DO - 10.1016/S1072-7515(00)00252-0 ID - Botti2000 ER - TY - JOUR AU - Reinholz, M. M. AU - Bruzek, A. K. AU - Visscher, D. W. AU - Lingle, W. L. AU - Schroeder, M. J. AU - Perez, E. A. AU - Jenkins, R. B. PY - 2009 DA - 2009// TI - Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response JO - Lancet Oncol VL - 10 UR - https://doi.org/10.1016/S1470-2045(09)70063-4 DO - 10.1016/S1470-2045(09)70063-4 ID - Reinholz2009 ER - TY - JOUR AU - Salido, M. AU - Tusquets, I. AU - Corominas, J. M. AU - Suarez, M. AU - Espinet, B. AU - Corzo, C. AU - Bellet, M. AU - Fabregat, X. AU - Serrano, S. AU - Sole, F. PY - 2005 DA - 2005// TI - Polysomy of chromosome 17 in breast cancer tumors showing an overexpression of ERBB2: a study of 175 cases using fluorescence in situ hybridization and immunohistochemistry JO - Breast Cancer Res VL - 7 UR - https://doi.org/10.1186/bcr996 DO - 10.1186/bcr996 ID - Salido2005 ER - TY - JOUR AU - Dal Lago, L. AU - Durbecq, V. AU - Desmedt, C. AU - Salgado, R. AU - Verjat, T. AU - Lespagnard, L. AU - Ma, Y. AU - Veys, I. AU - Di Leo, A. AU - Sotiriou, C. PY - 2006 DA - 2006// TI - Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer JO - Mol Cancer Ther VL - 5 UR - https://doi.org/10.1158/1535-7163.MCT-06-0129 DO - 10.1158/1535-7163.MCT-06-0129 ID - Dal Lago2006 ER - TY - JOUR AU - Hyun, C. L. AU - Lee, H. E. AU - Kim, K. S. AU - Kim, S. W. AU - Kim, J. H. AU - Choe, G. AU - Park, S. Y. PY - 2008 DA - 2008// TI - The effect of chromosome 17 polysomy on HER-2/neu status in breast cancer JO - J Clin Pathol VL - 61 UR - https://doi.org/10.1136/jcp.2007.050336 DO - 10.1136/jcp.2007.050336 ID - Hyun2008 ER - TY - JOUR AU - Vranic, S. AU - Teruya, B. AU - Repertinger, S. AU - Ulmer, P. AU - Hagenkord, J. AU - Gatalica, Z. PY - 2011 DA - 2011// TI - Assessment of HER2 gene status in breast carcinomas with polysomy of chromosome 17 JO - Cancer VL - 117 UR - https://doi.org/10.1002/cncr.25580 DO - 10.1002/cncr.25580 ID - Vranic2011 ER - TY - JOUR AU - Yeh, I. T. AU - Martin, M. A. AU - Robetorye, R. S. AU - Bolla, A. R. AU - McCaskill, C. AU - Shah, R. K. AU - Gorre, M. E. AU - Mohammed, M. S. AU - Gunn, S. R. PY - 2009 DA - 2009// TI - Clinical validation of an array CGH test for HER2 status in breast cancer reveals that polysomy 17 is a rare event JO - Mod Pathol VL - 22 UR - https://doi.org/10.1038/modpathol.2009.78 DO - 10.1038/modpathol.2009.78 ID - Yeh2009 ER - TY - JOUR AU - Viale, G. PY - 2009 DA - 2009// TI - Be precise! The need to consider the mechanisms for CEP17 copy number changes in breast cancer JO - J Pathol VL - 219 UR - https://doi.org/10.1002/path.2593 DO - 10.1002/path.2593 ID - Viale2009 ER - TY - JOUR AU - Marchio, C. AU - Lambros, M. B. AU - Gugliotta, P. AU - Di Cantogno, L. V. AU - Botta, C. AU - Pasini, B. AU - Tan, D. S. AU - Mackay, A. AU - Fenwick, K. AU - Tamber, N. PY - 2009 DA - 2009// TI - Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis JO - J Pathol VL - 219 UR - https://doi.org/10.1002/path.2574 DO - 10.1002/path.2574 ID - Marchio2009 ER - TY - JOUR AU - Moelans, C. B. AU - de Weger, R. A. AU - van Diest, P. J. PY - 2010 DA - 2010// TI - Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification JO - Breast Cancer Res Treat VL - 120 UR - https://doi.org/10.1007/s10549-009-0539-2 DO - 10.1007/s10549-009-0539-2 ID - Moelans2010 ER - TY - JOUR AU - Tse, C. H. AU - Hwang, H. C. AU - Goldstein, L. C. AU - Kandalaft, P. L. AU - Wiley, J. C. AU - Kussick, S. J. AU - Gown, A. M. PY - 2011 DA - 2011// TI - Determining true HER2 gene status in breast cancers with polysomy by using alternative chromosome 17 reference genes: implications for anti-HER2 targeted therapy JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2011.36.0107 DO - 10.1200/JCO.2011.36.0107 ID - Tse2011 ER - TY - JOUR AU - Moelans, C. B. AU - Reis-Filho, J. S. AU - van Diest, P. J. PY - 2011 DA - 2011// TI - Implications of rarity of chromosome 17 polysomy in breast cancer JO - Lancet Oncol VL - 12 UR - https://doi.org/10.1016/S1470-2045(11)70234-0 DO - 10.1016/S1470-2045(11)70234-0 ID - Moelans2011 ER - TY - JOUR AU - Bartlett, J. M. AU - Munro, A. F. AU - Dunn, J. A. AU - McConkey, C. AU - Jordan, S. AU - Twelves, C. J. AU - Cameron, D. A. AU - Thomas, J. AU - Campbell, F. M. AU - Rea, D. W. PY - 2010 DA - 2010// TI - Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601) JO - Lancet Oncol VL - 11 UR - https://doi.org/10.1016/S1470-2045(10)70006-1 DO - 10.1016/S1470-2045(10)70006-1 ID - Bartlett2010 ER - TY - JOUR AU - Pauletti, G. AU - Godolphin, W. AU - Press, M. F. AU - Slamon, D. J. PY - 1996 DA - 1996// TI - Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization JO - Oncogene VL - 13 ID - Pauletti1996 ER - TY - JOUR AU - Tanner, M. AU - Jarvinen, P. AU - Isola, J. PY - 2001 DA - 2001// TI - Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer JO - Cancer Res VL - 61 ID - Tanner2001 ER - TY - JOUR AU - Slamon, D. J. AU - Clark, G. M. AU - Wong, S. G. AU - Levin, W. J. AU - Ullrich, A. AU - McGuire, W. L. PY - 1987 DA - 1987// TI - Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene JO - Science VL - 235 UR - https://doi.org/10.1126/science.3798106 DO - 10.1126/science.3798106 ID - Slamon1987 ER - TY - JOUR AU - Jarvinen, T. A. AU - Liu, E. T. PY - 2006 DA - 2006// TI - Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes–molecular basis for combination chemotherapy in cancer JO - Curr Cancer Drug Targets VL - 6 UR - https://doi.org/10.2174/156800906778742497 DO - 10.2174/156800906778742497 ID - Jarvinen2006 ER - TY - JOUR AU - Hayes, D. F. AU - Thor, A. D. AU - Dressler, L. G. AU - Weaver, D. AU - Edgerton, S. AU - Cowan, D. AU - Broadwater, G. AU - Goldstein, L. J. AU - Martino, S. AU - Ingle, J. N. PY - 2007 DA - 2007// TI - HER2 and response to paclitaxel in node-positive breast cancer JO - N Engl J Med VL - 357 UR - https://doi.org/10.1056/NEJMoa071167 DO - 10.1056/NEJMoa071167 ID - Hayes2007 ER - TY - JOUR AU - Gennari, A. AU - Sormani, M. P. AU - Pronzato, P. AU - Puntoni, M. AU - Colozza, M. AU - Pfeffer, U. AU - Bruzzi, P. PY - 2008 DA - 2008// TI - HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials JO - J Natl Cancer Inst VL - 100 UR - https://doi.org/10.1093/jnci/djm252 DO - 10.1093/jnci/djm252 ID - Gennari2008 ER - TY - JOUR AU - Di Leo, A. AU - Larsimont, D. AU - Gancberg, D. AU - Jarvinen, T. AU - Beauduin, M. AU - Vindevoghel, A. AU - Michel, J. AU - Focan, C. H. AU - Ries, F. AU - Gobert, P. H. PY - 2001 DA - 2001// TI - HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide JO - Ann Oncol VL - 12 UR - https://doi.org/10.1023/A:1011669223035 DO - 10.1023/A:1011669223035 ID - Di Leo2001 ER - TY - JOUR AU - Konecny, G. E. AU - Thomssen, C. AU - Luck, H. J. AU - Untch, M. AU - Wang, H. J. AU - Kuhn, W. AU - Eidtmann, H. AU - du Bois, A. AU - Olbricht, S. AU - Steinfeld, D. PY - 2004 DA - 2004// TI - Her-2/neu gene amplification and response to paclitaxel in patients with metastatic breast cancer JO - J Natl Cancer Inst VL - 96 UR - https://doi.org/10.1093/jnci/djh198 DO - 10.1093/jnci/djh198 ID - Konecny2004 ER - TY - JOUR AU - Kellner, U. AU - Sehested, M. AU - Jensen, P. B. AU - Gieseler, F. AU - Rudolph, P. PY - 2002 DA - 2002// TI - Culprit and victim – DNA topoisomerase II JO - Lancet Oncol VL - 3 UR - https://doi.org/10.1016/S1470-2045(02)00715-5 DO - 10.1016/S1470-2045(02)00715-5 ID - Kellner2002 ER - TY - JOUR AU - Beser, A. R. AU - Tuzlali, S. AU - Guzey, D. AU - Dolek Guler, S. AU - Hacihanefioglu, S. AU - Dalay, N. PY - 2007 DA - 2007// TI - HER-2, TOP2A and chromosome 17 alterations in breast cancer JO - Pathol Oncol Res VL - 13 UR - https://doi.org/10.1007/BF02893497 DO - 10.1007/BF02893497 ID - Beser2007 ER - TY - JOUR AU - Champoux, J. J. PY - 2001 DA - 2001// TI - DNA topoisomerases: structure, function, and mechanism JO - Annu Rev Biochem VL - 70 UR - https://doi.org/10.1146/annurev.biochem.70.1.369 DO - 10.1146/annurev.biochem.70.1.369 ID - Champoux2001 ER - TY - JOUR AU - Ju, B. G. AU - Lunyak, V. V. AU - Perissi, V. AU - Garcia-Bassets, I. AU - Rose, D. W. AU - Glass, C. K. AU - Rosenfeld, M. G. PY - 2006 DA - 2006// TI - A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription JO - Science VL - 312 UR - https://doi.org/10.1126/science.1127196 DO - 10.1126/science.1127196 ID - Ju2006 ER - TY - JOUR AU - Jarvinen, T. A. AU - Tanner, M. AU - Barlund, M. AU - Borg, A. AU - Isola, J. PY - 1999 DA - 1999// TI - Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer JO - Genes Chromosomes Cancer VL - 26 UR - https://doi.org/3.0.CO;2-B DO - 3.0.CO;2-B ID - Jarvinen1999 ER - TY - JOUR AU - Knoop, A. S. AU - Knudsen, H. AU - Balslev, E. AU - Rasmussen, B. B. AU - Overgaard, J. AU - Nielsen, K. V. AU - Schonau, A. AU - Gunnarsdottir, K. AU - Olsen, K. E. AU - Mouridsen, H. PY - 2005 DA - 2005// TI - Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.11.007 DO - 10.1200/JCO.2005.11.007 ID - Knoop2005 ER - TY - JOUR AU - Schindlbeck, C. AU - Mayr, D. AU - Olivier, C. AU - Rack, B. AU - Engelstaedter, V. AU - Jueckstock, J. AU - Jenderek, C. AU - Andergassen, U. AU - Jeschke, U. AU - Friese, K. PY - 2010 DA - 2010// TI - Topoisomerase IIalpha expression rather than gene amplification predicts responsiveness of adjuvant anthracycline-based chemotherapy in women with primary breast cancer JO - Cancer Res Clin Oncol VL - 136 UR - https://doi.org/10.1007/s00432-009-0748-4 DO - 10.1007/s00432-009-0748-4 ID - Schindlbeck2010 ER - TY - JOUR AU - Simon, R. M. AU - Paik, S. AU - Hayes, D. F. PY - 2009 DA - 2009// TI - Use of archived specimens in evaluation of prognostic and predictive biomarkers JO - J Natl Cancer Inst VL - 101 UR - https://doi.org/10.1093/jnci/djp335 DO - 10.1093/jnci/djp335 ID - Simon2009 ER - TY - JOUR AU - Fountzilas, G. AU - Skarlos, D. AU - Dafni, U. AU - Gogas, H. AU - Briasoulis, E. AU - Pectasides, D. AU - Papadimitriou, C. AU - Markopoulos, C. AU - Polychronis, A. AU - Kalofonos, H. P. PY - 2005 DA - 2005// TI - Postoperative dose-dense sequential chemotherapy with epirubicin, followed by CMF with or without paclitaxel, in patients with high-risk operable breast cancer: a randomized phase III study conducted by the Hellenic Cooperative Oncology Group JO - Ann Oncol VL - 16 UR - https://doi.org/10.1093/annonc/mdi366 DO - 10.1093/annonc/mdi366 ID - Fountzilas2005 ER - TY - JOUR AU - Fountzilas, G. AU - Dafni, U. AU - Gogas, H. AU - Linardou, H. AU - Kalofonos, H. P. AU - Briasoulis, E. AU - Pectasides, D. AU - Samantas, E. AU - Bafaloukos, D. AU - Stathopoulos, G. P. PY - 2008 DA - 2008// TI - Postoperative dose-dense sequential chemotherapy with epirubicin, paclitaxel and CMF in patients with high-risk breast cancer: safety analysis of the Hellenic Cooperative Oncology Group randomized phase III trial HE 10/00 JO - Ann Oncol VL - 19 UR - https://doi.org/10.1093/annonc/mdm539 DO - 10.1093/annonc/mdm539 ID - Fountzilas2008 ER - TY - JOUR AU - Gogas, H. AU - Dafni, U. AU - Karina, M. AU - Papadimitriou, C. AU - Batistatou, A. AU - Bobos, M. AU - Kalofonos, H. P. AU - Eleftheraki, A. G. AU - Timotheadou, E. AU - Bafaloukos, D. PY - 2012 DA - 2012// TI - Postoperative dose-dense sequential versus concomitant administration of epirubicin and paclitaxel in patients with node-positive breast cancer: 5-year results of the Hellenic Cooperative Oncology Group HE 10/00 phase III Trial JO - Breast Cancer Res Treatment VL - 132 UR - https://doi.org/10.1007/s10549-011-1913-4 DO - 10.1007/s10549-011-1913-4 ID - Gogas2012 ER - TY - JOUR AU - Fountzilas, G. AU - Dafni, U. AU - Bobos, M. AU - Batistatou, A. AU - Kotoula, V. AU - Trihia, H. AU - Malamou-Mitsi, V. AU - Miliaras, S. AU - Chrisafi, S. AU - Papadopoulos, S. PY - 2012 DA - 2012// TI - Differential response of immunohistochemically defined breast cancer subtypes to anthracycline-based adjuvant chemotherapy with or without paclitaxel JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0037946 DO - 10.1371/journal.pone.0037946 ID - Fountzilas2012 ER - TY - JOUR AU - Razis, E. AU - Bobos, M. AU - Kotoula, V. AU - Eleftheraki, A. G. AU - Kalofonos, H. P. AU - Pavlakis, K. AU - Papakostas, P. AU - Aravantinos, G. AU - Rigakos, G. AU - Efstratiou, I. PY - 2011 DA - 2011// TI - Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer JO - Breast Cancer Research Treat VL - 128 UR - https://doi.org/10.1007/s10549-011-1572-5 DO - 10.1007/s10549-011-1572-5 ID - Razis2011 ER - TY - JOUR AU - McShane, L. M. AU - Altman, D. G. AU - Sauerbrei, W. AU - Taube, S. E. AU - Gion, M. AU - Clark, G. M. PY - 2006 DA - 2006// TI - REporting recommendations for tumor MARKer prognostic studies (REMARK) JO - Breast Cancer Res Treat VL - 100 UR - https://doi.org/10.1007/s10549-006-9242-8 DO - 10.1007/s10549-006-9242-8 ID - McShane2006 ER - TY - JOUR AU - Kononen, J. AU - Bubendorf, L. AU - Kallioniemi, A. AU - Barlund, M. AU - Schraml, P. AU - Leighton, S. AU - Torhorst, J. AU - Mihatsch, M. J. AU - Sauter, G. AU - Kallioniemi, O. P. PY - 1998 DA - 1998// TI - Tissue microarrays for high-throughput molecular profiling of tumor specimens JO - Nat Med VL - 4 UR - https://doi.org/10.1038/nm0798-844 DO - 10.1038/nm0798-844 ID - Kononen1998 ER - TY - JOUR AU - Skacel, M. AU - Skilton, B. AU - Pettay, J. D. AU - Tubbs, R. R. PY - 2002 DA - 2002// TI - Tissue microarrays: a powerful tool for high-throughput analysis of clinical specimens: a review of the method with validation data JO - Appl Immunohistochem Mol Morphol VL - 10 ID - Skacel2002 ER - TY - JOUR AU - Fountzilas, G. AU - Kourea, H. P. AU - Bobos, M. AU - Televantou, D. AU - Kotoula, V. AU - Papadimitriou, C. AU - Papazisis, K. T. AU - Timotheadou, E. AU - Efstratiou, I. AU - Koutras, A. PY - 2011 DA - 2011// TI - Paclitaxel and bevacizumab as first line combined treatment in patients with metastatic breast cancer: the Hellenic Cooperative Oncology Group experience with biological marker evaluation JO - Anticancer Res VL - 31 ID - Fountzilas2011 ER - TY - JOUR AU - Christodoulou, C. AU - Kostopoulos, I. AU - Kalofonos, H. P. AU - Lianos, E. AU - Bobos, M. AU - Briasoulis, E. AU - Gogas, H. AU - Razis, E. AU - Skarlos, D. V. AU - Fountzilas, G. PY - 2009 DA - 2009// TI - Trastuzumab combined with pegylated liposomal doxorubicin in patients with metastatic breast cancer. phase II Study of the Hellenic Cooperative Oncology Group (HeCOG) with biomarker evaluation JO - Oncology VL - 76 UR - https://doi.org/10.1159/000207504 DO - 10.1159/000207504 ID - Christodoulou2009 ER - TY - JOUR AU - Wolff, A. C. AU - Hammond, M. E. AU - Schwartz, J. N. AU - Hagerty, K. L. AU - Allred, D. C. AU - Cote, R. J. AU - Dowsett, M. AU - Fitzgibbons, P. L. AU - Hanna, W. M. AU - Langer, A. PY - 2007 DA - 2007// TI - American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer JO - J Clin Oncol VL - 25 UR - https://doi.org/10.1200/JCO.2006.09.2775 DO - 10.1200/JCO.2006.09.2775 ID - Wolff2007 ER - TY - JOUR AU - Hammond, M. E. AU - Hayes, D. F. AU - Dowsett, M. AU - Allred, D. C. AU - Hagerty, K. L. AU - Badve, S. AU - Fitzgibbons, P. L. AU - Francis, G. AU - Goldstein, N. S. AU - Hayes, M. PY - 2010 DA - 2010// TI - American society of clinical oncology/college of American pathologists guideline recommendations for immunohistochemical testing of Estrogen and progesterone receptors in breast cancer JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.25.6529 DO - 10.1200/JCO.2009.25.6529 ID - Hammond2010 ER - TY - JOUR AU - Cheang, M. C. AU - Chia, S. K. AU - Voduc, D. AU - Gao, D. AU - Leung, S. AU - Snider, J. AU - Watson, M. AU - Davies, S. AU - Bernard, P. S. AU - Parker, J. S. PY - 2009 DA - 2009// TI - Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer JO - J Natl Cancer Inst VL - 101 UR - https://doi.org/10.1093/jnci/djp082 DO - 10.1093/jnci/djp082 ID - Cheang2009 ER - TY - JOUR AU - Bhargava, R. AU - Lal, P. AU - Chen, B. PY - 2005 DA - 2005// TI - HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: chromogenic in situ hybridization and immunohistochemical analyses JO - Am J Clin Pathol VL - 123 UR - https://doi.org/10.1309/PCFK8YTQPYWD534F DO - 10.1309/PCFK8YTQPYWD534F ID - Bhargava2005 ER - TY - JOUR AU - Press, M. F. AU - Sauter, G. AU - Buyse, M. AU - Bernstein, L. AU - Guzman, R. AU - Santiago, A. AU - Villalobos, I. E. AU - Eiermann, W. AU - Pienkowski, T. AU - Martin, M. PY - 2011 DA - 2011// TI - Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2009.27.5644 DO - 10.1200/JCO.2009.27.5644 ID - Press2011 ER - TY - JOUR AU - Vanden Bempt, I. AU - Van Loo, P. AU - Drijkoningen, M. AU - Neven, P. AU - Smeets, A. AU - Christiaens, M. R. AU - Paridaens, R. AU - De Wolf-Peeters, C. PY - 2008 DA - 2008// TI - Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing JO - J Clin Oncol VL - 26 UR - https://doi.org/10.1200/JCO.2007.13.4296 DO - 10.1200/JCO.2007.13.4296 ID - Vanden Bempt2008 ER - TY - JOUR AU - Perez, E. A. AU - Reinholz, M. M. AU - Hillman, D. W. AU - Tenner, K. S. AU - Schroeder, M. J. AU - Davidson, N. E. AU - Martino, S. AU - Sledge, G. W. AU - Harris, L. N. AU - Gralow, J. R. PY - 2010 DA - 2010// TI - HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.26.2154 DO - 10.1200/JCO.2009.26.2154 ID - Perez2010 ER - TY - JOUR AU - Dafni, U. AU - Bobos, M. AU - Tsolaki, E. AU - Batistatou, A. AU - Koletsa, F. AU - Televantou, D. AU - Gogas, H. AU - Linardou, H. AU - Pectasides, D. AU - Kalogeras, K. T. AU - Galani, E. AU - Koutras, A. AU - Papadimitriou, C. A. AU - Fountzilas, G. PY - 2011 DA - 2011// TI - Effect of HER2/Topoisomerase II alpha (TOP2A) Gene Status or Protein Expression and Chromosome 17 (CEP17) Polysomy on the Outcome of Breast Cancer Patients Treated with Anthracycline-Containing Dose-Dense Sequential Adjuvant Chemotherapy with or without Paclitaxel. A pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials JO - Cancer Res VL - 71 UR - https://doi.org/10.1158/0008-5472.SABCS11-PD05-02 DO - 10.1158/0008-5472.SABCS11-PD05-02 ID - Dafni2011 ER - TY - JOUR AU - Sauter, G. AU - Lee, J. AU - Bartlett, J. M. AU - Slamon, D. J. AU - Press, M. F. PY - 2009 DA - 2009// TI - Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations JO - J Clin Oncol VL - 27 UR - https://doi.org/10.1200/JCO.2007.14.8197 DO - 10.1200/JCO.2007.14.8197 ID - Sauter2009 ER - TY - JOUR AU - Hudis, C. A. AU - Barlow, W. E. AU - Costantino, J. P. AU - Gray, R. J. AU - Pritchard, K. I. AU - Chapman, J. A. AU - Sparano, J. A. AU - Hunsberger, S. AU - Enos, R. A. AU - Gelber, R. D. PY - 2007 DA - 2007// TI - Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system JO - J Clin Oncol VL - 25 UR - https://doi.org/10.1200/JCO.2006.10.3523 DO - 10.1200/JCO.2006.10.3523 ID - Hudis2007 ER - TY - JOUR AU - Clark, G. M. AU - McGuire, W. L. PY - 1991 DA - 1991// TI - Follow-up study of HER-2/neu amplification in primary breast cancer JO - Cancer Res VL - 51 ID - Clark1991 ER - TY - JOUR AU - Allred, D. C. AU - Clark, G. M. AU - Tandon, A. K. AU - Molina, R. AU - Tormey, D. C. AU - Osborne, C. K. AU - Gilchrist, K. W. AU - Mansour, E. G. AU - Abeloff, M. AU - Eudey, L. PY - 1992 DA - 1992// TI - HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma JO - J Clin Oncol VL - 10 ID - Allred1992 ER - TY - JOUR AU - Bonnefoi, H. R. PY - 2011 DA - 2011// TI - Anthracyclines, HER2, and TOP2A: the verdict JO - Lancet Oncol VL - 12 UR - https://doi.org/10.1016/S1470-2045(11)70241-8 DO - 10.1016/S1470-2045(11)70241-8 ID - Bonnefoi2011 ER - TY - JOUR AU - Di Leo, A. AU - Desmedt, C. AU - Bartlett, J. M. AU - Piette, F. AU - Ejlertsen, B. AU - Pritchard, K. I. AU - Larsimont, D. AU - Poole, C. AU - Isola, J. AU - Earl, H. PY - 2011 DA - 2011// TI - HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data JO - Lancet Oncol VL - 12 UR - https://doi.org/10.1016/S1470-2045(11)70231-5 DO - 10.1016/S1470-2045(11)70231-5 ID - Di Leo2011 ER - TY - JOUR AU - Hicks, D. G. AU - Tubbs, R. R. PY - 2005 DA - 2005// TI - Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines JO - Hum Pathol VL - 36 UR - https://doi.org/10.1016/j.humpath.2004.11.010 DO - 10.1016/j.humpath.2004.11.010 ID - Hicks2005 ER - TY - JOUR AU - Nielsen, K. V. AU - Ejlertsen, B. AU - Moller, S. AU - Jensen, M. B. AU - Balslev, E. AU - Muller, S. AU - Knoop, A. AU - Mouridsen, H. T. PY - 2012 DA - 2012// TI - Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status JO - Mol Oncol VL - 6 UR - https://doi.org/10.1016/j.molonc.2011.11.006 DO - 10.1016/j.molonc.2011.11.006 ID - Nielsen2012 ER - TY - JOUR AU - O’Malley, F. P. AU - Chia, S. AU - Tu, D. AU - Shepherd, L. E. AU - Levine, M. N. AU - Bramwell, V. H. AU - Andrulis, I. L. AU - Pritchard, K. I. PY - 2009 DA - 2009// TI - Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy JO - J Natl Cancer Inst VL - 101 UR - https://doi.org/10.1093/jnci/djp067 DO - 10.1093/jnci/djp067 ID - O’Malley2009 ER - TY - JOUR AU - Varga, Z. AU - Tubbs, R. R. AU - Wang, Z. AU - Sun, Y. AU - Noske, A. AU - Kradolfer, D. AU - Bosshard, G. AU - Jochum, W. AU - Moch, H. AU - Ohlschlegel, C. PY - 2012 DA - 2012// TI - Co-amplification of the HER2 gene and chromosome 17 centromere: a potential diagnostic pitfall in HER2 testing in breast cancer JO - Breast Cancer Res Treat VL - 132 UR - https://doi.org/10.1007/s10549-011-1642-8 DO - 10.1007/s10549-011-1642-8 ID - Varga2012 ER - TY - JOUR AU - She, X. AU - Horvath, J. E. AU - Jiang, Z. AU - Liu, G. AU - Furey, T. S. AU - Christ, L. AU - Clark, R. AU - Graves, T. AU - Gulden, C. L. AU - Alkan, C. PY - 2004 DA - 2004// TI - The structure and evolution of centromeric transition regions within the human genome JO - Nature VL - 430 UR - https://doi.org/10.1038/nature02806 DO - 10.1038/nature02806 ID - She2004 ER - TY - JOUR AU - Baehner, F. L. AU - Achacoso, N. AU - Maddala, T. AU - Shak, S. AU - Quesenberry, C. P. AU - Goldstein, L. C. AU - Gown, A. M. AU - Habel, L. A. PY - 2010 DA - 2010// TI - Human epidermal growth factor receptor 2 assessment in a case–control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2009.24.8211 DO - 10.1200/JCO.2009.24.8211 ID - Baehner2010 ER - TY - JOUR AU - Zaczek, A. AU - Markiewicz, A. AU - Supernat, A. AU - Bednarz-Knoll, N. AU - Brandt, B. AU - Seroczynska, B. AU - Skokowski, J. AU - Szade, J. AU - Czapiewski, P. AU - Biernat, W. PY - 2012 DA - 2012// TI - Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer JO - Pathol Oncol Res VL - 18 UR - https://doi.org/10.1007/s12253-012-9518-8 DO - 10.1007/s12253-012-9518-8 ID - Zaczek2012 ER - TY - JOUR AU - Munro, A. F. AU - Cameron, D. A. AU - Bartlett, J. M. PY - 2010 DA - 2010// TI - Targeting anthracyclines in early breast cancer: new candidate predictive biomarkers emerge JO - Oncogene VL - 29 UR - https://doi.org/10.1038/onc.2010.286 DO - 10.1038/onc.2010.286 ID - Munro2010 ER - TY - JOUR AU - Pritchard, K. I. AU - Munro, A. AU - O’Malley, F. P. AU - Tu, D. AU - Li, X. AU - Levine, M. N. AU - Shepherd, L. AU - Chia, S. AU - Bartlett, J. M. PY - 2012 DA - 2012// TI - Chromosome 17 centromere (CEP17) duplication as a predictor of anthracycline response: evidence from the NCIC Clinical Trials Group (NCIC CTG) MA.5 Trial JO - Breast Cancer Res Treat VL - 131 UR - https://doi.org/10.1007/s10549-011-1840-4 DO - 10.1007/s10549-011-1840-4 ID - Pritchard2012 ER - TY - JOUR AU - Kim, A. AU - Shin, H. C. AU - Bae, Y. K. AU - Kim, M. K. AU - Kang, S. H. AU - Lee, S. J. AU - Lee, E. H. PY - 2012 DA - 2012// TI - Multiplication of Chromosome 17 Centromere Is Associated with Prognosis in Patients with Invasive Breast Cancers Exhibiting Normal HER2 and TOP2A Status JO - J Breast Cancer VL - 15 UR - https://doi.org/10.4048/jbc.2012.15.1.24 DO - 10.4048/jbc.2012.15.1.24 ID - Kim2012 ER - TY - JOUR AU - Vanden Bempt, I. AU - Drijkoningen, M. AU - De Wolf-Peeters, C. PY - 2007 DA - 2007// TI - The complexity of genotypic alterations underlying HER2-positive breast cancer: an explanation for its clinical heterogeneity JO - Curr Opin Oncol VL - 19 UR - https://doi.org/10.1097/CCO.0b013e3282f0ad8e DO - 10.1097/CCO.0b013e3282f0ad8e ID - Vanden Bempt2007 ER - TY - JOUR AU - Hayashi, N. AU - Nakamura, S. AU - Yagata, H. AU - Shimoda, Y. AU - Ota, H. AU - Hortobagyi, G. N. AU - Cristofanilli, M. AU - Ueno, N. T. PY - 2011 DA - 2011// TI - Chromosome 17 polysomy in circulating tumor cells in patients with metastatic breast cancer: a case series JO - Int J Clin Oncol VL - 16 UR - https://doi.org/10.1007/s10147-010-0173-3 DO - 10.1007/s10147-010-0173-3 ID - Hayashi2011 ER - TY - JOUR AU - Torrisi, R. AU - Rotmensz, N. AU - Bagnardi, V. AU - Viale, G. AU - Curto, B. D. AU - Dell’orto, P. AU - Veronesi, P. AU - Luini, A. AU - D’Alessandro, C. AU - Cardillo, A. PY - 2007 DA - 2007// TI - HER2 status in early breast cancer: relevance of cell staining patterns, gene amplification and polysomy 17 JO - Eur J Cancer VL - 43 UR - https://doi.org/10.1016/j.ejca.2007.07.033 DO - 10.1016/j.ejca.2007.07.033 ID - Torrisi2007 ER - TY - JOUR AU - Krishnamurti, U. AU - Hammers, J. L. AU - Atem, F. D. AU - Storto, P. D. AU - Silverman, J. F. PY - 2009 DA - 2009// TI - Poor prognostic significance of unamplified chromosome 17 polysomy in invasive breast carcinoma JO - Mod Pathol VL - 22 UR - https://doi.org/10.1038/modpathol.2009.61 DO - 10.1038/modpathol.2009.61 ID - Krishnamurti2009 ER - TY - JOUR AU - Watters, A. D. AU - Going, J. J. AU - Cooke, T. G. AU - Bartlett, J. M. PY - 2003 DA - 2003// TI - Chromosome 17 aneusomy is associated with poor prognostic factors in invasive breast carcinoma JO - Breast Cancer Res Treat VL - 77 UR - https://doi.org/10.1023/A:1021399923825 DO - 10.1023/A:1021399923825 ID - Watters2003 ER - TY - JOUR AU - Bose, S. AU - Mohammed, M. AU - Shintaku, P. AU - Rao, P. N. PY - 2001 DA - 2001// TI - Her-2/neu gene amplification in low to moderately expressing breast cancers: possible role of chromosome 17/Her-2/neu polysomy JO - Breast J VL - 7 UR - https://doi.org/10.1046/j.1524-4741.2001.21018.x DO - 10.1046/j.1524-4741.2001.21018.x ID - Bose2001 ER - TY - JOUR AU - Ross, J. S. PY - 2010 DA - 2010// TI - Human epidermal growth factor receptor 2 testing in 2010: does chromosome 17 centromere copy number make any difference? JO - J Clin Oncol VL - 28 UR - https://doi.org/10.1200/JCO.2010.29.6673 DO - 10.1200/JCO.2010.29.6673 ID - Ross2010 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/13/163/prepub UR - http://www.biomedcentral.com/1471-2407/13/163/prepub ID - ref80 ER -