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Table 3 Univariate and multivariate analyses of factors associated with OS and TTR

From: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

  

OS

 

TTR

   

Multivariate

  

Multivariate

Factors

Univariate p

HR

95% Cl

p

Univariate p

HR

95% Cl

p

Sex: Male vs Female

0.870

  

NA

0.547

  

NA

Age: < 50 vs >50

0.241

  

NA

0.131

  

NA

HBsAg: positive vs negative

0.166

  

NA

0.178

  

NA

Cirrhosis: yes vs no

0.077

  

NA

0.135

  

NA

serum AFP (ng/ml): ≤ 20 vs > 20

0.005

  

NA

0.031

  

NA

Child-pugh: A vs B vs C

0.284

  

NA

0.225

  

NA

TNM: I vs II vs III-IV

0.000

1.534

1.262-1.864

0.000

0.000

1.496

1.243-1.801

0.000

tumor differentiation:

  well vs moderate vs Poor

0.025

  

NS

0.236

  

NA

vascular invasion: yes vs no

0.002

  

NS

0.013

  

NA

ACY1: low vs high

0.930

  

NA

0.687

  

NA

SQSTM1: low vs high

0.438

  

NA

0.932

  

NA

GPC3: low vs high

0.001

  

NS

0.004

  

NS

AFP and GPC3 combination

  A-/G high vs A-/G low or A+/ G high vs A+/G low

0.000

1.811

1.439-2.279

0.000

0.000

1.530

1.233-1.898

0.000

  1. NOTE: Univariate analysis was calculated by the Kaplan–Meier method (the log-rank test). Multivariate analysis was done using the Cox multivariate proportional hazard regression model with stepwise manner (forward, likelihood ratio). AFP, α-fetoprotein; A-, AFP negative; A+, AFP positive; G high, GPC3 high; G low, GPC3 low; TTR, time to recurrence; OS, overall survival; NS, not significant; NA, not adopted; HR, hazard ratio; Cl, confidential interval.