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Table 3 Univariate and multivariate analyses of factors associated with OS and TTR

From: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

   OS   TTR
    Multivariate    Multivariate
Factors Univariate p HR 95% Cl p Univariate p HR 95% Cl p
Sex: Male vs Female 0.870    NA 0.547    NA
Age: < 50 vs >50 0.241    NA 0.131    NA
HBsAg: positive vs negative 0.166    NA 0.178    NA
Cirrhosis: yes vs no 0.077    NA 0.135    NA
serum AFP (ng/ml): ≤ 20 vs > 20 0.005    NA 0.031    NA
Child-pugh: A vs B vs C 0.284    NA 0.225    NA
TNM: I vs II vs III-IV 0.000 1.534 1.262-1.864 0.000 0.000 1.496 1.243-1.801 0.000
tumor differentiation:
  well vs moderate vs Poor 0.025    NS 0.236    NA
vascular invasion: yes vs no 0.002    NS 0.013    NA
ACY1: low vs high 0.930    NA 0.687    NA
SQSTM1: low vs high 0.438    NA 0.932    NA
GPC3: low vs high 0.001    NS 0.004    NS
AFP and GPC3 combination
  A-/G high vs A-/G low or A+/ G high vs A+/G low 0.000 1.811 1.439-2.279 0.000 0.000 1.530 1.233-1.898 0.000
  1. NOTE: Univariate analysis was calculated by the Kaplan–Meier method (the log-rank test). Multivariate analysis was done using the Cox multivariate proportional hazard regression model with stepwise manner (forward, likelihood ratio). AFP, α-fetoprotein; A-, AFP negative; A+, AFP positive; G high, GPC3 high; G low, GPC3 low; TTR, time to recurrence; OS, overall survival; NS, not significant; NA, not adopted; HR, hazard ratio; Cl, confidential interval.