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Table 2 Sensitivity, specificity, positive and negative predictive values for WDHCC detection using individual markers and marker combinations

From: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

 

WDHCC (n = 32)

HGDN (n = 21)

Sen

Spe

PPV

NPV

ACY1 negative

24

1

75.0%

95.2%

96.0%

71.4%

SQSTM1 positive

27

4

84.4%

81.0%

87.1%

77.3%

GPC3 positive

20

1

62.5%

95.2%

95.2%

95.2%

Predicted by ACY1 + SQSTM1

27

20

84.4%

95.2%

96.4%

80.0%

Predicted by ACY1 + GPC3

28

13

87.5%

61.9%

77.8%

76.5%

Predicted by SQSTM1 + GPC3

30

17

93.8%

81.0%

88.2%

89.5%

Predicted by ACY1 + SQSTM1 + GPC3

30

20

93.8%

95.2%

96.8%

90.9%

  1. NOTE. LGDN, low grade dysplastic nodule; HGDN, high grade dysplastic nodule; WDHCC, welldifferentiated hepatocellular carcinoma; MDHCC, moderately differentiated hepatocellular carcinoma; Sen, sensitivity; Spe, specification; PPV, positive predictive value; NPV, negative predictive value.