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Table 2 Sensitivity, specificity, positive and negative predictive values for WDHCC detection using individual markers and marker combinations

From: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

  WDHCC (n = 32) HGDN (n = 21) Sen Spe PPV NPV
ACY1 negative 24 1 75.0% 95.2% 96.0% 71.4%
SQSTM1 positive 27 4 84.4% 81.0% 87.1% 77.3%
GPC3 positive 20 1 62.5% 95.2% 95.2% 95.2%
Predicted by ACY1 + SQSTM1 27 20 84.4% 95.2% 96.4% 80.0%
Predicted by ACY1 + GPC3 28 13 87.5% 61.9% 77.8% 76.5%
Predicted by SQSTM1 + GPC3 30 17 93.8% 81.0% 88.2% 89.5%
Predicted by ACY1 + SQSTM1 + GPC3 30 20 93.8% 95.2% 96.8% 90.9%
  1. NOTE. LGDN, low grade dysplastic nodule; HGDN, high grade dysplastic nodule; WDHCC, welldifferentiated hepatocellular carcinoma; MDHCC, moderately differentiated hepatocellular carcinoma; Sen, sensitivity; Spe, specification; PPV, positive predictive value; NPV, negative predictive value.