A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

Table 1 Immunoreaction score distribution of ACY1, SQSTM1, and GPC3 according to histologic grade in LGDN, HGDN, WDHCC, and MDHCC

			ACY1	%	SQSTM1	%	GPC3	%
25	LGDN	-	3	12.0	21	84.0	25	100.0
	(n = 25)	+	16	64.0	2	8.0	0	0.0
		++	6	24.0	2	8.0	0	0.0
		+++	0	0.0	0	0.0	0	0.0
21	HGDN	-	1	4.8	17	81.0	20	95.2
	(n = 21)	+	14	66.7	2	9.5	1	4.8
		++	6	28.6	2	9.5	0	0.0
		+++	0	0.0	0	0.0	0	0.0
32	WDHCC	-	24	75.0	5	15.6	12	37.5
	(n = 32)	+	6	18.8	12	37.5	11	34.4
		++	2	6.3	11	34.4	5	15.6
		+++	0	0.0	4	12.5	4	12.5
19	MDHCC	-	17	89.5	3	15.8	6	31.6
	(n = 19)	+	2	10.5	3	15.8	3	15.8
		++	0	0.0	3	15.8	7	36.8
		+++	0	0.0	10	52.6	3	15.8
	r		−0.639		0.644		0.616
	p		< 0.0001		< 0.0001		< 0.0001

NOTE. LGDN, low grade dysplastic nodule; HGDN, high grade dysplastic nodule; WDHCC, welldifferentiated hepatocellular carcinoma; MDHCC, moderately differentiated hepatocellular carcinoma; r, correlation coefficient; p, spearman correlation (from LGDN to MDHCC).

ISSN: 1471-2407