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Table 1 Immunoreaction score distribution of ACY1, SQSTM1, and GPC3 according to histologic grade in LGDN, HGDN, WDHCC, and MDHCC

From: A novel panel of biomarkers in distinction of small well-differentiated HCC from dysplastic nodules and outcome values

    ACY1 % SQSTM1 % GPC3 %
25 LGDN - 3 12.0 21 84.0 25 100.0
  (n = 25) + 16 64.0 2 8.0 0 0.0
   ++ 6 24.0 2 8.0 0 0.0
   +++ 0 0.0 0 0.0 0 0.0
21 HGDN - 1 4.8 17 81.0 20 95.2
  (n = 21) + 14 66.7 2 9.5 1 4.8
   ++ 6 28.6 2 9.5 0 0.0
   +++ 0 0.0 0 0.0 0 0.0
32 WDHCC - 24 75.0 5 15.6 12 37.5
  (n = 32) + 6 18.8 12 37.5 11 34.4
   ++ 2 6.3 11 34.4 5 15.6
   +++ 0 0.0 4 12.5 4 12.5
19 MDHCC - 17 89.5 3 15.8 6 31.6
  (n = 19) + 2 10.5 3 15.8 3 15.8
   ++ 0 0.0 3 15.8 7 36.8
   +++ 0 0.0 10 52.6 3 15.8
  r   −0.639   0.644   0.616  
  p   < 0.0001   < 0.0001   < 0.0001  
  1. NOTE. LGDN, low grade dysplastic nodule; HGDN, high grade dysplastic nodule; WDHCC, welldifferentiated hepatocellular carcinoma; MDHCC, moderately differentiated hepatocellular carcinoma; r, correlation coefficient; p, spearman correlation (from LGDN to MDHCC).