Genetic variants in PARP1 (rs3219090) and IRF4(rs12203592) genes associated with melanoma susceptibility in a Spanish population

Table 4 MM associated SNPs with statistically significant associations in any of the three penetrance models analysed

Gene	SNP	Penetrance model		Non adjusted		Adjusted
Gene	SNP	Penetrance model		OR (CI 95%)	p-value	OR (CI 95%)	p-value
PARP1	rs3219090	Codominant	GG/AG/AA	0.79 (0.63-0.97)	0.027	0.82 (0.62-1.07)	0.151
		Dominant	GG/AG + AA	0.76 (0.57-1.01)	0.059	0.80 (0.56-1.15)	0.228
		Recessive	GG + AG/AA	0.66 (0.41-1.05)	0.079	0.7 (0.38-1.28)	0.246
IRF4	rs12203592	Codominant	CC/CT/TT	0.97 (0.74-1.26)	0.801	0.76 (0.53-1.08)	0.122
		Dominant	CC/CT + TT	0.83 (0.61- 1.12)	0.214	0.65 (0.44-0.98)	0.037
		Recessive	CC + CT/TT	6.28 (1.45-27.13)	0.014	4.07 (0.83-20.05)	0.084
NADSYN1	rs12785878	Codominant	TT/GT/GG	0.84 (0.68-1.04)	0.106	0.83 (0.64-1.08)	0.165
		Dominant	TT/GT + GG	0.76 (0.57-1.02)	0.065	0.76 (0.53-1.10)	0.142
		Recessive	TT + GT/GG	0.89 (0.58-1.35)	0.575	0.84 (0.49-1.44)	0.522
ATM	rs1801516	Codominant	GG/AG/AA	0.83 (0.62-1.11)	0.203	0.88 (0.61-1.28)	0.504
		Dominant	GG/AG + AA	0.84 (0.6-1.18)	0.318	0.92 (0.59-1.41)	0.686
		Recessive	GG + AG/AA	0.56 (0.23-1.36)	0.198	0.53 (0.15-1.8)	0.310

Bold indicates statistically significant results.
OR (CI 95%) means Odds Ratio and its 95% Confidence Interval.
The results are obtained taking into account three penetrance models: Codominant (major homozygotes versus heterozygotes versus minor homozygotes), Dominant (major homozygotes versus heterozygotes plus minor homozygotes) and Recessive (major homozygotes plus heterozygotes versus minor homozygotes).
Adjusted for eye color, hair color, lentigines and childhood sunburn via multivariate analysis by performing logistic regression.

ISSN: 1471-2407