Table 3 Genotypic analyses of all the SNPs studied and their association with MM susceptibility in Spanish population
Gene | SNP | Controls N (%) | Cases N (%) | Association | |||||
|---|---|---|---|---|---|---|---|---|---|
Major homozygotes | Heterozygotes | Minor homozygotes | Major homozygotes | Heterozygotes | Minor homozygotes | OR (CI 95%) | p-value | ||
PARP1 | rs3219090 | 149 (46.4) | 133 (41.4) | 39 (12.1) | 255 (53.2) | 184 (38.4) | 40 (8.3) | 0.79 (0.63-0.97) | 0.027 |
ATM | rs1801516 | 232 (74.6) | 68 (21.0) | 11 (3.5) | 349 (77.7) | 91 (20.3) | 9 (2) | 0.83 (0.62-1.11) | 0.203 |
CASP8 | rs13016963 | 112 (34.3) | 158 (48.5) | 56 (17.2) | 174 (35.5) | 241 (49.2) | 75 (15.3) | 0.94 (0.77-1.15) | 0.539 |
MX2 | rs45430 | 123 (38.3) | 152 (47.3) | 46 (14.3) | 180 (37.6) | 221 (46.2) | 77 (16.1) | 1.05 (0.86-1.29) | 0.627 |
CCND1 | rs1485993 | 93 (29.5) | 162 (51.4) | 60 (19.1) | 143 (30.7) | 237 (51) | 85 (18.3) | 0.96 (0.78-1.18) | 0.691 |
IRF4 | rs12203592 | 242 (70.1) | 101 (29.3) | 2 (0.6) | 398 (74) | 121 (22.5) | 19 (3.5) | 0.97 (0.74-1.26) | 0.801 |
CYP2R1 | rs10741657 | 123 (40.6) | 131 (43.2) | 49 (16.2) | 172 (38.1) | 214 (47.4) | 65 (14.4) | 1.01 (0.82-1.25) | 0.893 |
NADSYN1 | rs7944926 | 138 (43) | 138 (43) | 45 (14) | 210 (45.5) | 195 (42.3) | 56 (12.1) | 0.91 (0.74-1.12) | 0.380 |
NADSYN1 | rs12785878 | 130 (39.3) | 157 (47.4) | 44 (13.3) | 211 (45.9) | 194 (42.2) | 55 (11.9) | 0.84 (0.68-1.04) | 0.106 |