Figure 7
From: Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc −/+ ice
Silibinin affects Ki67 expression in Apc −/+ mice. Representative examples of immunohistochemical analysis of Ki67 in Apc −/+ control (A) and silibinin treated mice (B). Quantification of Ki67 immunostaining within the adenomas (C) and within the crypts (D) in control (empty bar) and silibinin treated mice area (filled bar). (*p < 0.01 compared with control, by t test. n = 4 animals/group).