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Table 3 Multivariable Cox PH analyses for OS and RFS

From: 53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19–9 in pancreatic adenocarcinoma

 

Overall survival

Recurrence free survival

Variables

HR

95% CI

p value

HR

95% CI

p value

Age at surgery 1, a

1.27

0.84–1.91

0.255

1.00

0.67–1.48

0.982

Lymph node ratio

  

0.007 b,*

1.02

 

0.020 b,*

 Within High 53BP1 level strata 2, a

0.98

0.43–2.22

0.958

3.92

0.45–2.29

0.963

 Within Low 53BP1 level strata 2, a

4.84

2.26–10.37

<0.001*

 

1.79–8.58

<0.001*

CA19-9

  

0.040 b,*

  

0.226 b

 Within High 53BP1 level strata 3, a

0.87

0.52–1.47

0.606

0.94

0.56–1.57

0.803

 Within Low 53BP1 level strata 3, a

1.72

1.18–2.51

0.005*

1.38

0.97–1.96

0.077

Adjuvant chemotherapy: Yes

0.34

0.19–0.60

<0.001*

0.55

0.30–1.00

0.051

Margin Positive

2.37

1.35–4.14

0.003*

1.36

0.75–2.47

0.316

Peripancreatic extension status Positive

2.29

1.12–4.65

0.022*

2.41

1.16–5.01

0.019*

Perineural invasion status Positive

0.52

0.29–0.95

0.033*

0.46

0.25–0.81

0.008*

  1. a: upper quartile vs. lower quartile.
  2. b: P value for interaction terms with 53BP1 Level.
  3. 1: 73.10 vs. 58.38.
  4. 2: 25.69% vs. 0%.
  5. 3: 519.75 vs. 50.
  6. *: statistically significant.