Figure 1
Expression pattern of integrin receptors and type IV collagen in normal pancreatic tissue. A. H&E staining of normal exocrine pancreas with acini structures and a duct in the insert. The area shown is representative for all panels in B. B. Merged immunofluorescence staining of integrin α1, α2, and β1 (in red), and type IV collagen (green in upper row), or the endothelial marker CD31 (green in lower row). Type IV collagen is present in the vascular-, ductal-, and acini-BMs. Integrin α1 is only expressed in endothelial cells and integrin α2 only in the ductal epithelium. Integrin β1 is found in the ductal-, endothelial-, and at the base of the acini-cells. Arrows indicate examples of colocalization. Magnification x40 in all panels. Cell nuclei are stained by DAPI (in blue).