Table 3 Cox multivariate analysis of disease-free and overall survival
Recur HR (95% CI) | P-value | Death HR (95% CI) | P-value | |
|---|---|---|---|---|
Mode of BC Detection | ||||
Screen Detection | 1.00 | 1.00 | ||
Symptomatic | 2.02 (0.97–4.18) | .059 | 2.68 (0.92–7.77) | .07 |
Age | .21 | .001 | ||
<40 | 1.00 | 1.00 | ||
40–49 | 0.72 (0.34–1.54) | .42 | 1.24 (0.32–4.93) | .71 |
50–69 | 1.19 (0.62–2.28) | .63 | 3.61 (1.09–11.99) | .04 |
≥70 | 1.44 (0.67–3.08) | .35 | 6.56 (1.83–23.47) | .004 |
Tumor size | .12 | .14 | ||
T1 | 1.00 | 1.00 | ||
T2 | 1.36 (0.87–2.15) | .23 | 1.58 (0.86–2.91) | .11 |
T3–T4 | 2.03 (1.01–4.06) | .04 | 2.32 (0.96–5.6) | .06 |
No. of positive Lymph nodes | <.0001 | <.0001 | ||
All lymph nodes negative | 1.00 | 1.00 | ||
1–3 | 2.22 (1.28–3.84) | .004 | 1.66 (0.77–3.54) | .19 |
≥4 | 5.31 (3.15–8.96) | <.0001 | 6.09 (3.07–11.96) | <.0001 |
Molecular Subtypes* | <.0001 | .22 | ||
Luminal A | 1.00 | 1.00 | ||
Luminal B | 1.46 (0.86–2.47) | .21 | 1.04 (0.51–2.14) | .89 |
Non-Luminal HER2+ | 1.80 (0.97–3.35) | .06 | 2.23 (1.07–4.67) | .03 |
Non Basal-like | 1.75 (0.68–4.53) | .22 | 1.08 (0.25–4.67) | .91 |
Basal-like | 4.72 (2.13–10.46) | <.0001 | 2.06 (0.6–7.05) | .24 |