Table 2 Tumor characteristics, type of surgery, adjuvant treatment and survival outcomes by mode of breast cancer detection
MODE OF DETECTION | |||||
|---|---|---|---|---|---|
SYMPTOMATIC | SCREEN DETECTED | P-VALUE | |||
TUMOR CHARACTERISTICS | No. | % | No. | % | |
TOTAL | 334 | 74.5 | 114 | 25.5 | |
Tumor size | <.0001 | ||||
T1 | 166 | 51.7 | 84 | 80.8 | |
T2 | 123 | 38.3 | 19 | 18.3 | |
T3–T4 | 32 | 10.0 | 1 | 1.0 | |
No. of positive Lymph nodes | .01 | ||||
All lymph nodes negative | 167 | 52.8 | 73 | 70.2 | |
1–3 | 77 | 24.4 | 20 | 19.2 | |
4–9 | 52 | 16.5 | 9 | 8.7 | |
≥10 | 20 | 6.3 | 2 | 1.9 | |
Histological grade | <.0001 | ||||
1 | 23 | 7.2 | 20 | 18.5 | |
2 | 120 | 37.7 | 49 | 45.4 | |
3 | 175 | 55.0 | 39 | 36.1 | |
Immunoistochemical characteristics | |||||
ER status | .11 | ||||
Positive | 236 | 70.7 | 88 | 77.2 | |
Negative | 98 | 29.3 | 26 | 22.8 | |
PR status | .04 | ||||
Positive | 227 | 68.0 | 89 | 78.1 | |
Negative | 107 | 32.0 | 25 | 21.9 | |
Ki-67 | .02 | ||||
≤20% | 141 | 44.1 | 60 | 57.1 | |
>20% | 179 | 55.9 | 45 | 42.9 | |
HER2 status | .96 | ||||
0, 1+ | 227 | 70.1 | 76 | 70.4 | |
2+ | 46 | 14.2 | 16 | 14.8 | |
3+ | 51 | 15.7 | 16 | 14.8 | |
Molecular Subtypes | .04 | ||||
Luminal A | 193 | 59.0 | 74 | 68.5 | .09 |
Luminal B | 59 | 18.2 | 18 | 16.7 | .71 |
Non-Luminal HER2+ | 38 | 11.0 | 14 | 13.0 | .79 |
No Basal-like | 18 | 5.6 | 2 | 1.8 | .01 |
Basal-like | 16 | 4.9 | 0 | ||
TREATMENT CHARACTERISTICS | |||||
Type of surgery | .005 | ||||
Conservative | 242 | 74.7 | 88 | 88.0 | |
Mastectomy | 82 | 25.3 | 12 | 12.0 | |
Adjuvant Therapy | .04 | ||||
None | 36 | 11.8 | 15 | 13.6 | |
Radiation only | 64 | 21.1 | 37 | 33.6 | |
Chemotherapy only | 33 | 10.9 | 8 | 7.3 | |
Radiation and Chemotherapy | 171 | 56.2 | 50 | 45.5 | |
Hormone given | 244 | 81.3 | 92 | 83.6 | .23 |
OUTCOME CHARACTERISTICS | |||||
Vital status | <.0001 | ||||
Alive, no evidence of disease | 226 | 69.7 | 100 | 88.4 | |
Alive with this cancer | 40 | 12.3 | 5 | 4.4 | |
Dead, no evidence of disease | 4 | 1.2 | 0 | - | |
Dead from this cancer | 54 | 16.6 | 8 | 7.0 | |
Recurrence type | .001 | ||||
None | 230 | 71 | 100 | 88.5 | |
Loco-Regional | 18 | 5.6 | 3 | 2.7 | |
Distant | 76 | 23.5 | 10 | 8.8 | |