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Figure 1 | BMC Cancer

Figure 1

From: Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA Hypomethylation

Figure 1

Scheme to determine prototypical methylation pattern (PMP) and PMP-sim. PMP is a vector or length 501 corresponding to 501 samples. For each sample, if it is cancer or sperm sample, the corresponding PMP vector element is assigned the minimum methylation value among all 27578 CG loci for that sample, and if the sample is from normal somatic tissue cancer the corresponding PMP vector element is assigned the maximum methylation value among all 27578 CG loci for that sample. For any CG locus, given its methylation pattern across 501 samples, the Pearson correlation between the methylation pattern and the PMP-vector is used to estimate PMP-sim for the CG locus.

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BMC Cancer

ISSN: 1471-2407

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