Skip to main content
Figure 5 | BMC Cancer

Figure 5

From: TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

Figure 5

The sustained Akt activity confers resistance to MG132, TRAIL or MG132 plus TRAIL-induced apoptosis to NCI-H2452 cells. Western blotting demonstrates that transfection of the constitutively active Akt (myrAkt) results in a sustained phosphorylation of Akt at Ser 473 residue and reduces protein cleavages for caspases 3 and 7 and PARP induced by 1 μM MG132, 10 ng/ml TRAIL or MG132 plus TRAIL.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us