Figure 2

NURR1 protein expression correlates with specific prognostic indicators in breast cancer biopsies. Breast tumor microarray cores which were previously scored were categorized as either NURR1(-) (mean IHC score, < 1.5) or NURR1(+) (mean IHC score, ≥1.5). Subsequently, each category was compared with regard to several clinicopathological features (lymph node status, p53 status, ERα expression) using Fisher’s Exact Test. NURR1 is silenced in the primary tumors of patients with lymph node metastasis (A, p = 0.0292) and is inversely correlated to p53 expression (B, p = 0.0481). NURR1 status did not significantly correlate with ERα status (C, p = 0.1790) or histological grade (D, p = 0.928).