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Figure 1 | BMC Cancer

Figure 1

From: Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53

Figure 1

Intrinsic stability of p53 and Δ40p53 isoform. (A) Schematic representation of the domain structure of the p53 protein. The protein contains a major transactivation domain (MTA) with Hdm2-binding site (black bar with asterisk), a minor transactivation domain (mTA), a proline-rich domain (PXXP), a central DNA-binding domain (DBD), a C-terminal oligomerization domain (OD) and nuclear localization signals (NLS, light grey bars). (B) Endogenous levels of expression of TAp53 and Δ40p53 detected with DO-7 and Pab1801 antibody in HCT116 p53+/+ and 21PT cells, after cycloheximide (CHX) treatment (50 μg/ml) to block protein synthesis. Actin: loading control. Black arrow: TAp53, white arrow: Δ40p53.

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