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Table 1 Radiotherapy doses and fractionations

From: Early-stage squamous cell carcinoma of the oropharynx: Radiotherapy vs. Trans-Oral Robotic Surgery (ORATOR) – study protocol for a randomized phase II trial

Target volume Radical-intent dose* (Arm 1) Adjuvant dose (Arm 2)
Gross tumor and nodes 70 Gy in 35 fractions over 7 weeks N/A
Region of positive margins or extra-nodal extension N/A 64 Gy in 30 fractions over 6 weeks
High-risk nodal areas (and operative bed in Arm 2) 63 Gy in 35 fractions over 7 weeks 60 Gy in 30 fractions over 6 weeks
Low-risk nodal areas 56 Gy in 35 fractions over 7 weeks 54 Gy in 30 fractions over 6 weeks
  1. *In Arm 1, accelerated or hyperfractionated regimens may be used at the discretion of the radiation oncologist (e.g. same doses but delivered in 6 weeks).