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Table 1 Radiotherapy doses and fractionations

From: Early-stage squamous cell carcinoma of the oropharynx: Radiotherapy vs. Trans-Oral Robotic Surgery (ORATOR) – study protocol for a randomized phase II trial

Target volume

Radical-intent dose* (Arm 1)

Adjuvant dose (Arm 2)

Gross tumor and nodes

70 Gy in 35 fractions over 7 weeks

N/A

Region of positive margins or extra-nodal extension

N/A

64 Gy in 30 fractions over 6 weeks

High-risk nodal areas (and operative bed in Arm 2)

63 Gy in 35 fractions over 7 weeks

60 Gy in 30 fractions over 6 weeks

Low-risk nodal areas

56 Gy in 35 fractions over 7 weeks

54 Gy in 30 fractions over 6 weeks

  1. *In Arm 1, accelerated or hyperfractionated regimens may be used at the discretion of the radiation oncologist (e.g. same doses but delivered in 6 weeks).