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Table 4 Association between MDM2 SNP309 and gastric carcinoma in relation to location, metastasis and TNM stage

From: A functional polymorphism T309G in MDM2 gene promoter, intensified by Helicobacter pylori lipopolysaccharide, is associated with both an increased susceptibility and poor prognosis of gastric carcinoma in Chinese patients

Variable

MDM2SNP309 genotype (Control/Case)

Adjusted OR (95% CI) †

Pvalue

 

TT + TG

GG

TT + TG

GG

 

Location

     

  Cardia

495/141

79/40

1.00

1.84 (1.20-2.83)

< 0.01

  Non-cardia

495/292

79/101

1.00

2.18 (1.57-3.04)

< 0.01

Vascular invasion

     

  Absent

495/265

79/98

1.00

2.33 (1.67-3.26)

< 0.01

  Present

495/168

79/43

1.00

1.60 (1.06-2.42)

0.03

Lymph node metastasis

  

1.00

  

  Absent

495/138

79/35

1.00

1.59 (1.02-2.47)

0.04

  Present

495/295

79/106

1.00

2.25 (1.63-3.12)

< 0.01

Liver metastasis

  

1.00

  

  Absent

495/391

79/121

1.00

1.94 (1.42-2.65)

< 0.01

  Present

495/42

79/20

1.00

3.34 (1.84-6.08)

< 0.01

Peritoneal dissemination

     

  Absent

495/380

79/123

1.00

2.04 (1.49-2.79)

< 0.01

  Present

495/53

79/18

1.00

2.13 (1.18-3.84)

0.01

TNM stage

     

  IA

495/75

79/21

1.00

1.75 (1.01-3.00)

0.04

  IB

495/60

79/19

1.00

2.01 (1.13-3.57)

0.01

  II

495/83

79/24

1.00

1.78 (1.06-2.98)

0.03

  III

495/127

79/46

1.00

2.30 (1.52-3.49)

< 0.01

  IV

495/88

79/31

1.00

2.29 (1.42-3.69)

< 0.01

  1. †Adjusted for age, sex, and H. pylori infection.
  2. Abbreviations: OR, odds ratio; CI, confidence interval.