Time-dependent endpoints as predictors of overall survival in multiple myeloma

BMC Cancer

Table 3 Effect of median time-dependent endpoints (TDEs) on median overall survival estimate based on alternative modeling specifications

Specification	With censored observations (n = 230)			Without censored observations (n = 163)
	β	SE	95% CI	β	SE	95% CI
Base model (BM)^a	1.82	0.134	1.56 ; 2.08	2.09	0.206	1.69 ; 2.50
BM without two perturbing observations	1.84	0.137	1.58 ; 2.11	2.16	0.218	1.73 ; 2.58
BM with adjustment for type of patient and type of TDE^b	2.36	0.344	1.69 ; 3.04	2.64	0.568	1.52 ; 3.75
BM with adjustment for type of patient^c, type of TDE and treatment including Bort, or Len, or Thal	2.45	0.381	1.71 ; 3.20	2.62	0.558	1.52 ; 3.71

^aThe BM is adjusted for age, gender, and year of publication.
^bType of TDE refers to time to progression, progression-free survival, and event-free survival.
^cType of MM patient refers to the following groups: newly diagnosed; relapsed, refractory, or advanced; and mixed or not discriminated in the publication.
Abbreviations: β Regression coefficient, Bort Bortezomib, CI Confidence interval, Len Lenalidomide, MM Multiple myeloma, SE Standard error Thal Thalidomide.

ISSN: 1471-2407