Time-dependent endpoints as predictors of overall survival in multiple myeloma

BMC Cancer

Table 2 Effect of median time-dependent endpoints (TDEs) on median overall survival (OS) estimated from a multivariate censored normal regression, by type of TDE

Covariables	β	SE	P	95% CI
Median TDE, months	2.45	0.38	< 0.0001	1.71 ; 3.20
Females,%	0.05	0.24	0.83	− 0.42 ; 0.52
Median age, years	0.59	0.38	0.12	− 0.16 ; 1.34
Year of publication	0.24	0.32	0.46	− 0.39 ; 0.87
Relapsed, refractory, or advanced MM	14.24	7.60	0.06	− 0.66 ; 29.14
Mixed or not reported type MM	6.95	5.02	0.17	− 2.89 ; 16.78
TDE (time to progression)	5.95	4.16	0.15	− 2.21 ; 14.11
TDE (event-free survival)	− 3.51	4.03	0.38	− 11.42 ; 4.40
Treatment including Thal, Bort, or Len	− 5.98	6.08	0.33	− 17.89 ; 5.94

Note: Includes 163 uncensored observations and 67 right-censored observations. The constant of the model was suppressed due to non-significance.
Abbreviations: β Regression coefficient, Bort Bortezomib, CI Confidence interval Len Lenalidomide, MM, Multiple myeloma, SE, Standard error, Thal Thalidomide.

ISSN: 1471-2407