Time-dependent endpoints as predictors of overall survival in multiple myeloma

BMC Cancer

Table 1 Characteristics of the studies and patients included in the analysis

Characteristic	(n = 22,696)
Males,%	56.5
Age in years, mean of medians ± standard deviation^a	61.3 ± 7.2
Multiple myeloma, no. of patients (study arms)
Newly diagnosed	15,345 (128)
Relapsed, refractory, or advanced	5,273 (68)
Mixed or not reported^b	2,078 (34)
Duration of the studies (years), mean ± standard deviation	3.8 ± 2.0
Mean of median time-dependent endpoint, months (range)	22.5 (3–121)
Time to progression	16.7 (4–39)
Progression-free survival	22.7 (5–121)
Event-free survival	25.7 (3–70)
Median overall survival in months, mean (range)	39.1 (8–126)

^aAge statistics represent the mean of medians because the majority of studies reported the median rather than the mean age of the studied population.
^bCorresponds to those studies including: newly diagnosed; relapsed, refractory, or advanced; or to those not differentiating the type of patients.

ISSN: 1471-2407