Figure 2

Predicted median overall survival (OS) versus the observed OS in randomized controlled trials (RCTs) including thalidomide-, bortezomib-, or lenalidomide-based regimens for upfront treatment of multiple myeloma in patients not eligible for transplantation. Horizontal lines represent estimated 95% confidence interval (CI) for the median OS based on the modeled median time-dependent endpoints from each study arm. Solid circles represent observed median OS contained in the corresponding 95% CI estimate, and lozenges represent observed median OS not contained in the corresponding 95% CI estimate. Where data are from different studies, a direct comparison is not possible as different studies use different patient populations, different study designs, and were conducted at different time points. Vertical dashed line stands for the mean of median OS of the MP arms. ^a19.5% of trial patients received thalidomide maintenance therapy. ^b88% of patients received thalidomide maintenance therapy. ^c18.8% of trial patients received thalidomide maintenance therapy. ^d33–55% of trial patients received bortezomib maintenance therapy. ^e35% of trial patients received maintenance therapy with bortezomib plus prednisone and 33.5% with bortezomib plus thalidomide. ^f66.7% of patients received maintenance therapy with bortezomib plus thalidomide. ^g100% of patients planned to receive maintenance therapy with lenalidomide. Abbreviations: CTDa, attenuated (low-intensity) cyclophosphamide, thalidomide, dexamethasone; MP, melphalan, prednisone; MPR, melphalan, prednisone, lenalidomide; MPR-R, melphalan, prednisone, lenalidomide followed by maintenance with lenalidomide; MPT, melphalan, prednisone, thalidomide; Rd, lenalidomide, low-dose dexamethasone; RD, lenalidomide, dexamethasone; TD, thalidomide, dexamethasone; VD, bortezomib, dexamethasone; VMP, bortezomib, melphalan, prednisone; VMPT-VT, bortezomib, melphalan, prednisone, thalidomide followed by maintenance with bortezomib, thalidomide; VTP, bortezomib, thalidomide, prednisone.