Treatment-emergent | No | Eltrombopag | Eltrombopag | Eltrombopag | Total |
---|---|---|---|---|---|
Eltrombopag | 75 mg | 100 mg | 150 mg | (N = 15) | |
(n = 3)a | (n = 7) | (n = 4) | (n = 1) | ||
Hematologic AEs, n (%) | |||||
Thrombocytopenia | 2 (67) | 5 (71) | 4 (100) | 1 (100) | 12 (80) |
Neutropenia | 2 (67) | 5 (71) | 4 (100) | 0 | 11 (73) |
Anemia | 1 (33) | 6 (86) | 3 (75) | 0 | 10 (67) |
Leukopenia | 0 | 3 (43) | 2 (50) | 0 | 5 (33) |
Febrile neutropenia | 0 | 2 (29) | 1 (25) | 1 (100) | 4 (27) |
Thrombocytosis | 0 | 4 (57) | 0 | 0 | 4 (27) |
Nonhematologic AEs, n (%) | |||||
Fatigue | 0 | 6 (86) | 2 (50) | 0 | 8 (53) |
ALT increased | 0 | 5 (71) | 2 (50) | 0 | 7 (47) |
Constipation | 0 | 6 (86) | 1 (25) | 0 | 7 (47) |
Nausea | 1 (33) | 5 (71) | 1 (25) | 0 | 7 (47) |
Alopecia | 0 | 5 (71) | 1 (25) | 0 | 6 (40) |
Pyrexia | 1 (33) | 3 (43) | 2 (50) | 0 | 6 (40) |
Vomiting | 1 (33) | 3 (43) | 2 (50) | 0 | 6 (40) |
AST increased | 0 | 3 (43) | 2 (50) | 0 | 5 (33) |
Hypokalemia | 0 | 3 (43) | 2 (50) | 0 | 5 (33) |
Confusional state | 1 (33) | 2 (29) | 0 | 0 | 3 (20) |
Hemorrhoids | 0 | 3 (43) | 0 | 0 | 3 (20) |
Hypocalcemia | 0 | 1 (14) | 2 (50) | 0 | 3 (20) |
Headache | 0 | 3 (43) | 0 | 0 | 3 (20) |
Edema peripheral | 1 (33) | 1 (14) | 1 (25) | 0 | 3 (20) |
Proteinuria | 0 | 3 (43) | 0 | 0 | 3 (20) |
Vitamin B12 increased | 0 | 3 (43) | 0 | 0 | 3 (20) |