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Table 1 Case series characteristics and EGFR mutations distribution

From: Detection and characterization of classical and “uncommon” exon 19 Epidermal Growth Factor Receptor mutations in lung cancer by pyrosequencing

  N EGFR mutations
   Total mutated p value EXON 19 EXON 21
Total 321 61 (19.0%)   44 (72.1%) 17 (27.9%)
Sex      
 Male 186 (57.9%) 21 (11.3%) <0.0001 14 (66.7%) 7 (33.3%)
 Female 135 (42.1%) 40 (29.6%) 30 (75.0%) 10 (25.0%)
Surgical samples 75 (23.4%) 17 (22.6%) 0.40 10 (58.8%) 7 (41.2%)
Non surgical samples 246 (76.6%) 44 (17.8%) 34 (77.2%) 10 (22.7%)
 Biopsies 150 (46.7%) 26 (17.3%) 0.86 20 (76.9%) 6 (23.1%)
 Cytology (cell blocks) 87 (27.1%) 16 (18.3%) 14 (87.5%) 2 (12.5%)
 Cytology (smears) 9 (2.8%) 2 (22.2%)   0 2 (100%)
Location      
 Primary tumors 226 (70.4%) 45 (19.9%) 0.64 33 (73.3%) 12 (26.7%)
 Metastases 95 (29.6%) 16 (16.8%)   11 (68.8%) 5 (31.2%)
Diagnosis      
 ADC 269 (83.8%) 53 (19.7%) 0.83 37 (69.8%) 16 (30.2%)
 NSCLC (favor ADC) 37 (11.6%) 7 (18.9%)   7 (100%) 0 (0%)
 NSCLC NOS 4 (1.2%) 0   - -
 Non-ADC 11 (3.4%) 1 (9.1%)   0 (0%) 1 (100%)
  1. Legend: ADC: adenocarcinoma; NSCLC: non small cell lung cancer; NOS: non otherwise specified.