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Table 1 Relationship between change in mtDNA copy number and clinicopathological parameters

From: Association of decreased mitochondrial DNA content with the progression of colorectal cancer

Clinico-pathological parameter Group Number (n) Low mtDNA copy number (n) High mtDNA copy number (n) Χ 2 and Z P
Sex Male 30 17 12 1.669 0.196
  Female 30 13 18  
Age (years) <57 30 16 13 0.601 0.438
  ≥57 30 14 17  
Pathological stage Well differentiated 17 5 7 −1.321 0.186
  Moderately differentiated 31 14 17  
  Poorly differentiated 12 11 6  
Lymph node metastasis Positive 17 12 5 4.022 0.045*
  Negative 43 18 25   
TNM stage I 6 2 4 −1.604 0.109
  II 32 14 18  
  III 14 9 5  
  IV 8 5 3   
  1. * It indicated that the low mtDNA copy number correlated significantly with lymph node metastasis group (P=0.045, Table 1).