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Figure 1 | BMC Cancer

Figure 1

From: Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

Figure 1

Overexpression of HIF-1α in HCC is correlated with the level of SNAI1 and EMT markers and predicts poor prognosis. Immunohistochemistry was performed for determining the expression profile of various proteins, including HIF-1α (A, F), SNAI1 (B, G), E-cadherin (C, H), N-cadherin (D, I) and Vimentin (E, J), on HIF-1α+ (A-E) and HIF-1α- (F-J) HCC samples (A, D, F, I: ×200; B, C, E, G, H, J: ×400). (K) Disease-free survival after surgery was compared between HIF-1α positive (n = 43) and HIF-1α negative (n = 23) HCC patients.

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