|
Characteristics
|
Total
|
Aluminum content in mg/Kg
|
|---|
| | |
Mean (sd)
| |
Negative*
|
0.05 - 2.0
|
≥ 2
| |
|
Age
| | |
P**
|
n
|
(%)
|
n
|
(%)
|
n
|
(%)
|
P trend***
|
|
<40
|
20
|
1.13(1.59)
|
0.17
|
3
|
(14.3)
|
15
|
(12.8)
|
2
|
(16.7)
|
0.91
|
|
>4
0
|
130
|
1.76(11.90)
| |
18
|
(85.7)
|
102
|
(87.2)
|
10
|
(83.3)
| |
|
BMI
| | | | | | | | | | |
|
<25
|
46
|
3.68(19.9)
|
0.38
|
5
|
(33.3)
|
36
|
(35.6)
|
5
|
(55.6)
|
0.40
|
|
≥25
|
79
|
0.78(1.13)
| |
10
|
(66.7)
|
65
|
(64.4)
|
4
|
(44.4)
| |
|
Menopausal status
| | | | | | | | | | |
|
Post
|
42
|
4.06(20.88)
|
0.12
|
6
|
(35.3)
|
33
|
(31.7)
|
3
|
(30)
|
0.75
|
|
Pre
|
89
|
0.73(0.98)
| |
11
|
(64.7)
|
71
|
(68.3)
|
7
|
(70)
| |
|
Quadrant
| | | | | | | | | | |
|
Upper external
|
92
|
2.19(14.13)
|
0.59
|
15
|
(71.4)
|
70
|
(59.8)
|
7
|
(58.3)
|
0.37
|
|
Other
|
58
|
0.87(1.32)
| |
6
|
(28.6)
|
47
|
(40.2)
|
5
|
(41.7)
| |
|
Tumor size
| | | | | | | | | | |
|
<2.0 cm
|
72
|
0.78(0.94)
|
0.28
|
6
|
(30)
|
60
|
(51.7)
|
6
|
(50)
|
0.16
|
|
≥2.0 cm
|
76
|
2.56(15.56)
| |
14
|
(70)
|
56
|
(48.3)
|
6
|
(50)
| |
|
Stage
| | | | | | | | | | |
|
I-II
|
90
|
2.19(14.28)
|
0.42
|
10
|
(50)
|
74
|
(63.8)
|
6
|
(50)
|
0.75
|
|
III – IV
|
58
|
0.92(1.51)
| |
10
|
(50)
|
42
|
(36.2)
|
6
|
(50)
| |
|
Histologic grade
| | | | | | | | | | |
|
I-II
|
26
|
0.89(1.30)
|
0.53
|
4
|
(21.1)
|
20
|
(18.2)
|
2
|
(20)
|
0.88
|
|
III
|
113
|
1.89(12.75)
| |
15
|
(78.9)
|
90
|
(81.8)
|
8
|
(80)
| |
|
Estrogen receptor
| | | | | | | | | | |
|
Negative
|
40
|
0.56(0.49)
|
0.009
|
2
|
10
|
37
|
33.3
|
1
|
(8.3)
|
0.62
|
|
Positive
|
103
|
2.18(13.37)
| |
18
|
90
|
74
|
66.7
|
11
|
(91.7)
| |
|
Progesterone receptor
| | | | | | | | | | |
|
Negative
|
56
|
0.63(0.68)
|
0.04
|
4
|
(20)
|
49
|
(44.5
|
3
|
(25)
|
0.43
|
|
Positive
|
86
|
2.46(14.62)
| |
16
|
(80)
|
61
|
(55.5)
|
9
|
(75)
| |
|
cerbb2 status
| | | | | | | | | | |
|
Negative
|
94
|
0.82(1.19)
|
0.77
|
13
|
(68.4)
|
74
|
(67.9)
|
7
|
(58.3)
|
0.61
|
|
Positive
|
46
|
3.68(19.96)
| |
6
|
(31.6)
|
35
|
(32.1)
|
5
|
(41.7)
| |
- Note: The aluminum concentration was categorized as negative, 0.05-2.0 mg/ kg and ≥ 2.0 mg/ kg according to the three-tiered percentile distribution of the raw data. *Aluminum detection threshold for the GF-AAS was set at 0.05 mg/kg; ** In this column, the p values refer to the comparison of the mean Aluminum concentrations in each strata, using independent samples t-tests with the log-transformed (to base e) data; ***In this column, the p-values refer to the Chi-squares for trends; i.e. if p ≤ 0.05, there is a significant trend in Aluminum concentration related to the specified characteristic (see statistics for more details).
