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Table 3 Univariate and multivariate analyses of recurrence and survival (Cox regression)

From: BRCA1 and ERCC1mRNA levels are associated with lymph node metastasis in Chinese patients with colorectal cancer

Variables

Recurrence

Survival

HR (95% CI)

Pvalue

HR (95% CI)

Pvalue

Univariate analysis

    

Sex

    

Male/female

0.813 (0.479-1.518)

0.604

0.829 (0.424-1.618)

0.662

Age (yr)

    

≤ 60/> 60

1.506 (0.804-2.712)

0.163

1.822 (0.947-3.528)

0.065

Tumor size (cm)

    

≤ 5/> 5

0.876 (0.163-0.665)

0.687

0.880 (0.438-1.723)

0.704

Tumor location

    

Colon/rectum

0.812 (0.445-1.423)

0.518

0.904 (0.476-1.734)

0.778

Tumor differentiation

    

I-II/III-IV

1.212 (0.654-2.308)

0.501

1.151 (0.576-2.358)

0.650

Tumor status

    

T1-2/T3-4

0.866 (0.475-1.618)

0.687

1.020 (0.504-2.028)

0.904

Lymph node metastasis

    

N0/N1-2

2.707 (1.502-4.912)

0.011

2.812 (1.413-5.509)

0.012

TNM stage

    

I-II/III-IV

3.554 (1.932-6.526)

<0.001

3.385 (1.677-6.843)

<0.001

ERCC1 expression

    

Negative/positive

3.556 (1.919-6.932)

<0.001

4.038 (1.913-8.712)

<0.001

BRCA1 expression

    

Negative/positive

3.244 (1.191-7.012)

<0.001

4.033 (1.906-8.512)

<0.001

Multivariate analysis

    

LNM

    

N0/N1-2

0.210 (0.051-0.758)

0.018

0.196 (0.041-0.852)

0.028

TNM stage

    

I-II/III-IV

8.905 (2.072-38.190)

0.003

9.037 (1.703-48.105)

0.010

ERCC1 expression

    

Negative/positive

2.673 (1.134-6.011)

0.018

3.011 (1.236-7.95)

0.031

BRCA1 expression

    

Negative/positive

2.401 (1.115-5.722)

0.013

2.844 (1.106-7.44)

0.021

  1. HR: Hazard ratio; CI: Confidence interval.
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BMC Cancer

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