BRCA1 and ERCC1mRNA levels are associated with lymph node metastasis in Chinese patients with colorectal cancer

Table 2 ERCC1 expression and relationship with clinicopathological factors in CRC

Clinicopathological factors	n	ERCC1 expression		Pvalue¹
Clinicopathological factors	n	Negative	Positive	Pvalue¹
Sex
Male	61	29	32	0.325
Female	59	29	30
Age (yr)
≤ 60	80	38	42	0.367
> 60	40	20	20
Tumor size (cm)
≤ 5	84	42	42	0.157
> 5	36	16	20
Tumor location
Colon	45	19	26	0.521
Rectum	75	37	38
Tumor differentiation²
I-II	92	52	40	0.124
III-IV	28	12	16
Tumor status²
T1-2	42	20	22	0.404
T3-4	78	41	37
Lymph node metastasis²
N0	42	18	24	< 0.001
N1-2	78	70	8
TNM stage²
I-II	42	21	21	< 0.001
III-IV	78	65	13

¹Statistical analysis was estimated with χ² test, and P < 0.05 was considered statistically significant;
²Grading of differentiation status and TNM classification for colorectal cancer were based on the American Joint Committee on Cancer Cancer Staging Manual (7th edition, 2009). The tumors were classified into two groups: well differentiated (grades I and II) and poorly differentiated (grades III and IV).

ISSN: 1471-2407