Table 2 Specific hygenic measures

• Information of staff involved in the medical care/nursing of trial subjects (e.g. physicians, nurses, cleaning staff, physiotherapist),

• Proposal of serological testing of medical staff for H-1PV prior to the beginning and at the end of the trial (in order to document potential seroconversion),

• Consideration of a subject as potentially viremic until:

○ A seroconversion as proven by HIT or ELISA,

○ In the absence of a seroconversion until proven lack of virus shedding in urine, saliva, and feces,

• While a subject is considered as potentially viremic:

○ Isolate her/him in a single room with its own toilet,

○ Use disposable gloves, protection gown and mask for handling of study medication and

materials contaminated with ParvOryx, e.g. infusion materials,

○ Information of medical staff to use gloves, protection gown and mask when in physical contact with the patient,

○ Information of medical staff and visitors to use mask only when strictly omitting body contact with the subject during his/her isolation phase. Alternatively, the subject can wear a mask when in the same room with medical staff and visitors,

○ Information of hygiene staff to carry out a terminal disinfection after discharge of a subject from isolation,

○ In case of surface contamination the disinfection must be performed with Perform^®, 3%