Figure 6
From: Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors
Effect of erlotinib on cell growth. (A) Dose-response curves of parental H1650, resistant subline H1650-ER1, sorted ER1-SP and ER1-non SP cells following incubation with varying concentrations of erlotinib for 48 hr. Each data point represents the mean of three independent experiments. The error bars represent s.e.m. (n = 3). (B) Dose-response curves of parental H1650, sorted H1650-SP and H1650 - non SP cells following incubation with varying concentrations of erlotinib for 48 hr. Each data point represents the mean of six replicates. The error bars represent S.D. (n = 6). (C) Quantification of spheroid formation by 6000 H1650-ER1 cells per well under the continuous presence of erlotinib. Each data point represents the mean of two independent experiments. The error bars represent s.e.m. (n = 3).