Figure 4

Cisplatin sensitivity with snail and slug knockdown. Cells with snail and slug knockdowns were grown in 10 μM cisplatin for 48 hours and cell survival was determined by MTT assay. Approximately 75 ± 3.3% of the drug sensitive cells died after treatment compared to 37 ± 2.4% of the drug resistant cells. With snail and slug knockdown, cell death was significantly increased to 62 ± 2.5% (p-value = 0.005).