Table 3 Univariate analysis of overall (OS) and event-free survival (EFS) in T-ALL patients
From: Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
Variables | OSa (95% CI) | p b | HRc (Lower-Upper) | EFSa (95% CI) | p b | HRc (Lower-Upper) |
|---|---|---|---|---|---|---|
Age (Years) | ||||||
< 10 | 45.1 (48.9-74.5) | 0.275 | 0.77 (0.48-1.24) | 28.8 (30.8-57.8) | 0.044 | 0.58 (0.34-1.00) |
10-18 | 56.7 (60.7-88.0) | 51.2 (51.9-85.8) | ||||
WBC (x109/L) | ||||||
<50 | 47.6 (51.6-79.4) | 0.606 | 0.88 (0.55-1.42) | 41.3 (40.9-73.3) | 0.859 | 1.05 (0.63-1.76) |
≥50 | 53.3 (57.1-82.5) | 36.7 (39.2-68.5) | ||||
EGIL | ||||||
T-I | 33.3 (28.8-77.2) | 0.411 | 0.93 (0.74-1.18) | 31.3 (26.9-75.9) | 0.954 | 0.98 (0.77-1.24) |
T-II | 51.7 (48.2-88.7) | 36.4 (31.5-75.5) | ||||
T-III | 61.8 (56.1-90.7) | 45.0 (32.9-78.6) | ||||
T-IV | 51.0 (44.0-70.9) | 36.7 (30.2-60.9) | ||||
CD10 | ||||||
Positive | 52.8 (50.6-86.9) | 0.696 | 1.12 (0.63-1.97) | 48.1 (42.6-83.6) | 0.097 | 1.67 (0.89-3.08) |
Negative | 50.0 (54.1-79.4) | 28.8 (31.6-59.5) | ||||
Skin colour | ||||||
White | 55.0 (54.5-81.5) | 0.451 | 1.20 (0.74-1.96) | 33.3 (32.1-61.5) | 0.331 | 0.78 (0.46-1.30) |
Non-white | 47.4 (52.8-77.8) | 43.4 (45.9-75.9) | ||||
NOTCH1 | ||||||
Mutated | 53.3 (54.6-80.8) | 0.479 | 1.19 (0.73-1.93) | 34.2 (30.5-60.9) | 0.382 | 0.79 (0.47-1.34) |
WT | 48.7 (52.7-78.2) | 42.1 (45.5-74.2) | ||||
Type of mutation | ||||||
Point | 42.4 (32.4-61.9) | 0.031 | 0.43 (0.19-0.95) | 30.4 (19.1-51.4) | 0.289 | 0.65 (0.28-1.47) |
Complex | 66.7 (65.6-100.9) | 40.0 (31.4-79.4) | ||||
FBXW7 | ||||||
Mutated | 61.9 (54.8-102.3) | 0.512 | 1.28 (0.60-2.73) | 58.3 (38.9-104.9) | 0.586 | 1.29 (0.51-3.31) |
WT | 51.7 (59.2-82.3) | 41.4 (47.2-74.7) | ||||
NOTCH1-FBXW7 | ||||||
Mutated | 58.1 (62.5-89.6) | 0.319 | 1.32 (0.76-2.28) | 40.5 (37.6-72.3) | 0.286 | 0.71 (0.37-1.34) |
WT | 47.9 (50.7-82.3) | 48.5 (51.1-87.7) | ||||
SIL-TAL1 | ||||||
Positive | 37.8 (32.1-68.3) | 0.012 | 0.53 (0.32-0.88) | 18.2 (11.9-48.7) | 0.004 | 0.46 (0.26-0.81) |
Negative | 56.5 (60.9-81.9) | 43.8 (46.4-71.1) | ||||
HOX11L2 | ||||||
Expressed | 40.0 (13.4-44.6) | 0.469 | 0.74 (0.32-1.71) | 50.0 (14.3-50.2) | 0.806 | 1.14 (0.41-3.16) |
Absent | 48.6 (54.1-75.2) | 35.6 (39.3-63.6) | ||||
KRAS | ||||||
Mutated | 60.0 (32.7-78.1) | 0.585 | 1.32 (0.48-3.67) | 57.1 (21.4-79.7) | 0.584 | 1.38 (0.43-4.46) |
WT | 49.5 (55.7-77.9) | 36.9 (41.5-66.9) | ||||
PTEN | ||||||
Mutated | 44.4 (15.1-56.1) | 0.359 | 0.65 (0.26-1.66) | 30.8 (34.6-66.1) | 0.693 | 0.31 (0.53-1.51) |
WT | 57.5 (63.5-86.6) | 42.0 (41.0-71.8) | ||||
Induction Responsed | ||||||
Yes | 68.4 (76.2-106.9) | <0.001 | 3.45 (1.74-6.85) | 70.3 (75.5-107.7) | <0.001 | 3.54 (1.71-7.32) |
No | 33.3 (25.9-55.9) | 32.4 (23.4-48.6) | ||||