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Table 3 Univariate analysis of overall (OS) and event-free survival (EFS) in T-ALL patients

From: Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

Variables OSa (95% CI) p b HRc (Lower-Upper) EFSa (95% CI) p b HRc (Lower-Upper)
Age (Years)
   < 10 45.1 (48.9-74.5) 0.275 0.77 (0.48-1.24) 28.8 (30.8-57.8) 0.044 0.58 (0.34-1.00)
   10-18 56.7 (60.7-88.0)    51.2 (51.9-85.8)   
WBC (x109/L)
   <50 47.6 (51.6-79.4) 0.606 0.88 (0.55-1.42) 41.3 (40.9-73.3) 0.859 1.05 (0.63-1.76)
   ≥50 53.3 (57.1-82.5)    36.7 (39.2-68.5)   
EGIL
   T-I 33.3 (28.8-77.2) 0.411 0.93 (0.74-1.18) 31.3 (26.9-75.9) 0.954 0.98 (0.77-1.24)
   T-II 51.7 (48.2-88.7)    36.4 (31.5-75.5)   
   T-III 61.8 (56.1-90.7)    45.0 (32.9-78.6)   
   T-IV 51.0 (44.0-70.9)    36.7 (30.2-60.9)   
CD10
   Positive 52.8 (50.6-86.9) 0.696 1.12 (0.63-1.97) 48.1 (42.6-83.6) 0.097 1.67 (0.89-3.08)
   Negative 50.0 (54.1-79.4)    28.8 (31.6-59.5)   
Skin colour
   White 55.0 (54.5-81.5) 0.451 1.20 (0.74-1.96) 33.3 (32.1-61.5) 0.331 0.78 (0.46-1.30)
   Non-white 47.4 (52.8-77.8)    43.4 (45.9-75.9)   
NOTCH1
   Mutated 53.3 (54.6-80.8) 0.479 1.19 (0.73-1.93) 34.2 (30.5-60.9) 0.382 0.79 (0.47-1.34)
   WT 48.7 (52.7-78.2)    42.1 (45.5-74.2)   
Type of mutation
   Point 42.4 (32.4-61.9) 0.031 0.43 (0.19-0.95) 30.4 (19.1-51.4) 0.289 0.65 (0.28-1.47)
   Complex 66.7 (65.6-100.9)    40.0 (31.4-79.4)   
FBXW7
   Mutated 61.9 (54.8-102.3) 0.512 1.28 (0.60-2.73) 58.3 (38.9-104.9) 0.586 1.29 (0.51-3.31)
   WT 51.7 (59.2-82.3)    41.4 (47.2-74.7)   
NOTCH1-FBXW7
   Mutated 58.1 (62.5-89.6) 0.319 1.32 (0.76-2.28) 40.5 (37.6-72.3) 0.286 0.71 (0.37-1.34)
   WT 47.9 (50.7-82.3)    48.5 (51.1-87.7)   
SIL-TAL1
   Positive 37.8 (32.1-68.3) 0.012 0.53 (0.32-0.88) 18.2 (11.9-48.7) 0.004 0.46 (0.26-0.81)
   Negative 56.5 (60.9-81.9)    43.8 (46.4-71.1)   
HOX11L2
   Expressed 40.0 (13.4-44.6) 0.469 0.74 (0.32-1.71) 50.0 (14.3-50.2) 0.806 1.14 (0.41-3.16)
   Absent 48.6 (54.1-75.2)    35.6 (39.3-63.6)   
KRAS
   Mutated 60.0 (32.7-78.1) 0.585 1.32 (0.48-3.67) 57.1 (21.4-79.7) 0.584 1.38 (0.43-4.46)
   WT 49.5 (55.7-77.9)    36.9 (41.5-66.9)   
PTEN
   Mutated 44.4 (15.1-56.1) 0.359 0.65 (0.26-1.66) 30.8 (34.6-66.1) 0.693 0.31 (0.53-1.51)
   WT 57.5 (63.5-86.6)    42.0 (41.0-71.8)   
Induction Responsed
   Yes 68.4 (76.2-106.9) <0.001 3.45 (1.74-6.85) 70.3 (75.5-107.7) <0.001 3.54 (1.71-7.32)
   No 33.3 (25.9-55.9)    32.4 (23.4-48.6)   
  1. a Survival in percent; b Mantel-Cox (log-rank) test; c last category used as reference; d evaluated in day 30-33 of treatment; HR hazard risk, WT wild-type, WBC white blood cells count
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