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Table 1 Clinical, demographic and laboratorial features of T-ALL patients according to NOTCH1 status, 2001-2008

From: Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

Variable n (%) NOTCH1mut n (%) NOTCH1wt n (%) p value
Age (Years)     
   < 10 71 (51.4) 28 (46.7) 43 (55.1) 0.324
   10-18 67 (48.6) 32 (53.3) 35 (44.9)  
Gender     
   Male 100 (72.5) 46 (76.7) 54 (69.2) 0. 332
   Female 38 (27.5) 14 (23.3) 24 (30.8)  
WBC (×109/L)     
   <50 63 (45.7) 29 (48.3) 34 (43.6) 0.579
   ≥50 75 (54.3) 31 (51.7) 44 (56.4)  
Mediastinal massa     
   Yes 58 (44.6) 24 (42.9) 34 (45.9) 0.726
   No 72 (55.4) 32 (57.1) 40 (54.1)  
Skin colour     
   White 60 (43.5) 21 (35.0) 39 (50.0) 0.078
   Non-white 78 (56.5) 39 (65.0) 39 (50.0)  
T-ALL subtypesb     
   T-I 18 (13.8) 9 (15.5) 9 (12.5) 0.343
   T-II 29 (22.3) 9 (15.5) 20 (27.8)  
   T-III 34 (26.2) 18 (31.0) 16 (22.2)  
   T-IV 49 (37.7) 22 (37.9) 27 (37.5)  
CD10 statusc     
   positive 36 (31.0) 16 (30.2) 20 (31.7) 0.857
   negative 80 (69.0) 37 (69.8) 43 (68.3)  
Molecular Studies     
   SIL-TAL1 pos 37 (28.7) 19 (32.8) 18 (25.4) 0.355
   HOX11L2 pos 10 (8.4) 6 (11.1) 4 (6.2) 0.332
   FBXW7 mut 21 (19.1) 13 (24.1) 8 (14.3) 0.192
   KRAS mut 10 (9.5) 4 (7.7) 6 (11.3) 0.527
   PTEN mut 9 (9.4) 5 (10.9) 4 (8.0) 0.630
Total 138 (100) 60 (100) 78 (100)  
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