Table 1 Clinical, demographic and laboratorial features of T-ALL patients according to NOTCH1 status, 2001-2008
From: Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
Variable | n (%) | NOTCH1mut n (%) | NOTCH1wt n (%) | p value |
|---|---|---|---|---|
Age (Years) | ||||
< 10 | 71 (51.4) | 28 (46.7) | 43 (55.1) | 0.324 |
10-18 | 67 (48.6) | 32 (53.3) | 35 (44.9) | |
Gender | ||||
Male | 100 (72.5) | 46 (76.7) | 54 (69.2) | 0. 332 |
Female | 38 (27.5) | 14 (23.3) | 24 (30.8) | |
WBC (×109/L) | ||||
<50 | 63 (45.7) | 29 (48.3) | 34 (43.6) | 0.579 |
≥50 | 75 (54.3) | 31 (51.7) | 44 (56.4) | |
Mediastinal massa | ||||
Yes | 58 (44.6) | 24 (42.9) | 34 (45.9) | 0.726 |
No | 72 (55.4) | 32 (57.1) | 40 (54.1) | |
Skin colour | ||||
White | 60 (43.5) | 21 (35.0) | 39 (50.0) | 0.078 |
Non-white | 78 (56.5) | 39 (65.0) | 39 (50.0) | |
T-ALL subtypesb | ||||
T-I | 18 (13.8) | 9 (15.5) | 9 (12.5) | 0.343 |
T-II | 29 (22.3) | 9 (15.5) | 20 (27.8) | |
T-III | 34 (26.2) | 18 (31.0) | 16 (22.2) | |
T-IV | 49 (37.7) | 22 (37.9) | 27 (37.5) | |
CD10 statusc | ||||
positive | 36 (31.0) | 16 (30.2) | 20 (31.7) | 0.857 |
negative | 80 (69.0) | 37 (69.8) | 43 (68.3) | |
Molecular Studies | ||||
SIL-TAL1 pos | 37 (28.7) | 19 (32.8) | 18 (25.4) | 0.355 |
HOX11L2 pos | 10 (8.4) | 6 (11.1) | 4 (6.2) | 0.332 |
FBXW7 mut | 21 (19.1) | 13 (24.1) | 8 (14.3) | 0.192 |
KRAS mut | 10 (9.5) | 4 (7.7) | 6 (11.3) | 0.527 |
PTEN mut | 9 (9.4) | 5 (10.9) | 4 (8.0) | 0.630 |
Total | 138 (100) | 60 (100) | 78 (100) |