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Table 2 Regression analysis for risk factors of HCC among patients with hepatitis C genotype 1

From: TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

 

Univariate analysis

  
   

95% Confidence interval

Parameter

p -value

Odds ratio

Lower

Upper

Age §

0.000

1.076

1.053

1.098

Diabetes mellitus

0.369

1.412

0.691

2.886

Gender (male)

0.135

1.430

0.915

2.236

HBV infection

0.626

1.295

0.460

3.646

HCV viral load (106 IU/ml)

0.339

0.960

0.883

1.044

Obesity (BMI > 30)

0.153

1.668

0.867

3.211

C626G genotype ([CC+CG] vs. GG)

0.035

1.670

1.034

2.696

A683C genotype (AA vs. [AC+CC])

0.001

2.176

1.390

3.407

Combined 626C and 683AA risk genotype vs. all other combinations

0.002

1.940

1.280

2.940

 

Multivariate analysis*

  
   

95% Confidence interval

Parameter

p-value

Odds ratio

Lower

Upper

Age §

0.000

1.074

1.052

1.097

Combined 626C and 683AA risk genotype

0.007

1.975

1.205

3.236

  1. * including all significant parameters from univariate analysis, § OR (95% CI) per year