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Table 2 Regression analysis for risk factors of HCC among patients with hepatitis C genotype 1

From: TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

  Univariate analysis   
    95% Confidence interval
Parameter p -value Odds ratio Lower Upper
Age § 0.000 1.076 1.053 1.098
Diabetes mellitus 0.369 1.412 0.691 2.886
Gender (male) 0.135 1.430 0.915 2.236
HBV infection 0.626 1.295 0.460 3.646
HCV viral load (106 IU/ml) 0.339 0.960 0.883 1.044
Obesity (BMI > 30) 0.153 1.668 0.867 3.211
C626G genotype ([CC+CG] vs. GG) 0.035 1.670 1.034 2.696
A683C genotype (AA vs. [AC+CC]) 0.001 2.176 1.390 3.407
Combined 626C and 683AA risk genotype vs. all other combinations 0.002 1.940 1.280 2.940
  Multivariate analysis*   
    95% Confidence interval
Parameter p-value Odds ratio Lower Upper
Age § 0.000 1.074 1.052 1.097
Combined 626C and 683AA risk genotype 0.007 1.975 1.205 3.236
  1. * including all significant parameters from univariate analysis, § OR (95% CI) per year