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Table 1 Patient characteristics and distribution of DR4 genotypes

From: TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

 

Healthy controls

HCV(+) all without HCC

HCV(+) Cirrhosis (-) Without HCC

HCV(+) Cirrhosis (+) without HCC

HCV(+) Cirrhosis (+) with HCC

HBV(+) With HCC

Numbers

359

234

159

75

159

56

Median age (range)

59 (35-69)

52 (39-63)

46 (39-57)

55 (49-63)

62 (54-70)

60(24-83)

Male Gender (%)

51.4

66.2

65.2

69.7

58.6

75.0

HCV infection (%)

-

100

100

100

100

0

HCV genotype 1 (%)

-

100

100

100

100

-

HCV viral load(10 6 IU/ml) a)

-

2.04 ± 0.25

2.10 ± 0.29

1.86 ± 0.48

1.88 ± 0.36

-

HBV infection (%)

-

3.2

2.8

4.0

4.4

100

BMI > 30 (%)

-

17.1

15.0

21.7

26.2

21.4

Diabetes (%)

-

7.7

0.8

23.0

12.0

3.6

rs20575 (C626G) b)

349 (100)

233 (100)

159 (100)

74 (100)

159 (100)

56 (100)

   CC

62 (17.8)

56 (24.0)

38 (23.9)

18 (24.3)

40 (25.2)

9 (16.1)

   CG

166 (47.6)

108 (46.4)

74 (46.5)

34 (45.9)

87 (54.7)

30 (53.6)

   GG

121 (34.7)

69 (29.6)

47 (29.6)

22 (29.7)

32 (20.1)

17 (30.4)

Deviation from Hardy-Weinberg equilibrium c)

p = 0.74

p = 0.29

p = 0.43

p = 0.49

p = 0.27

p = 0.59

rs20576 (A683C) b)

359 (100)

234 (100)

159 (100)

75 (100)

159 (100)

56 (100)

   CC

19 (5.3)

10 (4.3)

6 (3.8)

4 (5.3)

5 (3.1)

1 (1.8)

   AC

125 (34.8)

85 (36.3)

59 (35.0)

26 (34.7)

33 (21.9)

17 (30.4)

   AA

215 (59.9)

139 (59.4)

94 (59.1)

45 (60.0)

121 (75.8)

38 (67.9)

Deviation from Hardy-Weinberg equilibrium c)

p = 0.88

p = 0.58

p = 0.49

p = 1.0

p = 0.17

p = 1.0

  1. a) Mean ± SEM, b) Number of patients (number/% of total), c) Fisher's exact test