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Table 1 Patient characteristics and distribution of DR4 genotypes

From: TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

  Healthy controls HCV(+) all without HCC HCV(+) Cirrhosis (-) Without HCC HCV(+) Cirrhosis (+) without HCC HCV(+) Cirrhosis (+) with HCC HBV(+) With HCC
Numbers 359 234 159 75 159 56
Median age (range) 59 (35-69) 52 (39-63) 46 (39-57) 55 (49-63) 62 (54-70) 60(24-83)
Male Gender (%) 51.4 66.2 65.2 69.7 58.6 75.0
HCV infection (%) - 100 100 100 100 0
HCV genotype 1 (%) - 100 100 100 100 -
HCV viral load(10 6 IU/ml) a) - 2.04 ± 0.25 2.10 ± 0.29 1.86 ± 0.48 1.88 ± 0.36 -
HBV infection (%) - 3.2 2.8 4.0 4.4 100
BMI > 30 (%) - 17.1 15.0 21.7 26.2 21.4
Diabetes (%) - 7.7 0.8 23.0 12.0 3.6
rs20575 (C626G) b) 349 (100) 233 (100) 159 (100) 74 (100) 159 (100) 56 (100)
   CC 62 (17.8) 56 (24.0) 38 (23.9) 18 (24.3) 40 (25.2) 9 (16.1)
   CG 166 (47.6) 108 (46.4) 74 (46.5) 34 (45.9) 87 (54.7) 30 (53.6)
   GG 121 (34.7) 69 (29.6) 47 (29.6) 22 (29.7) 32 (20.1) 17 (30.4)
Deviation from Hardy-Weinberg equilibrium c) p = 0.74 p = 0.29 p = 0.43 p = 0.49 p = 0.27 p = 0.59
rs20576 (A683C) b) 359 (100) 234 (100) 159 (100) 75 (100) 159 (100) 56 (100)
   CC 19 (5.3) 10 (4.3) 6 (3.8) 4 (5.3) 5 (3.1) 1 (1.8)
   AC 125 (34.8) 85 (36.3) 59 (35.0) 26 (34.7) 33 (21.9) 17 (30.4)
   AA 215 (59.9) 139 (59.4) 94 (59.1) 45 (60.0) 121 (75.8) 38 (67.9)
Deviation from Hardy-Weinberg equilibrium c) p = 0.88 p = 0.58 p = 0.49 p = 1.0 p = 0.17 p = 1.0
  1. a) Mean ± SEM, b) Number of patients (number/% of total), c) Fisher's exact test