Figure 1

Distribution of DYX1C1 mRNA expression stratified by ERα status. (A) Fold change of DYX1C1 mRNA when comparing the expression between ERα-positive and -negative tumors in CHARES. GAPDH was used for normalization. The bars indicate 1 standard deviation. (B) Boxplot of the distribution of DYX1C1 mRNA expression examined by qRT-PCR in the CAHRES cohort between ERα-positive and ERα-negative tumors. The expression of DYX1C1 is significantly higher in ERα-positive tumors (note that the y-axis is inverted in CAHRES, were a lower dCT value indicates a higher expression). (C) Boxplot of the distribution of DYX1C1 mRNA expression examined by Affymetrix microarray in the Uppsala cohort between ERα-positive and ERα-negative tumors. The expression is significantly higher in ERα-positive tumors. (D) Boxplot of the distribution of DYX1C1 mRNA expression examined by Affymetrix microarray in the Stockholm cohort between ERα-positive and ERα-negative tumors. The expression is significantly higher in ERα-positive tumors.