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Table 3 Relationship between intensity of BRMS1 expression, ulceration, tumor thickness and markers of proliferation

From: Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

   Intensity of cytoplasmic
BRMS1 staining
 
Clinical parameter Expression Weak Stronga P
   Mean tumor depth (mm)   3.26 (3.11)b 1.92 (1.89) 0.024
   Ulceration No 71 23  
  Yes 44 2 0.004
   Marker     
  Low 53 19  
   Cyclin A High 65 6 0.007
  Low 70 20  
   Ki67 High 48 5 0.068
   Cyclin D3 Low 76 23  
  High 42 2 0.008
  Low 32 17  
   p21 High 31 3 0.009
  1. aLow protein expression was defined as immunoreactivity in less than 5% of the tumor cells
  2. (cyclin A, Ki67, cyclin D3, p21)[21, 22, 24]
  3. bSD