Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

BMC Cancer

Table 3 Relationship between intensity of BRMS1 expression, ulceration, tumor thickness and markers of proliferation

		Intensity of cytoplasmic BRMS1 staining
Clinical parameter	Expression	Weak	Strong^a	P
Mean tumor depth (mm)		3.26 (3.11)^b	1.92 (1.89)	0.024
Ulceration	No	71	23
	Yes	44	2	0.004
Marker
	Low	53	19
Cyclin A	High	65	6	0.007
	Low	70	20
Ki67	High	48	5	0.068
Cyclin D3	Low	76	23
	High	42	2	0.008
	Low	32	17
p21	High	31	3	0.009

^aLow protein expression was defined as immunoreactivity in less than 5% of the tumor cells
(cyclin A, Ki67, cyclin D3, p21)[21, 22, 24]
^bSD

ISSN: 1471-2407