Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

BMC Cancer

Table 2 Relationship between cytoplasmic BRMS1 score index, ulceration, tumor thickness, cyclin D3 and activation of ERK1/2 and Akt

		Cytoplasmic BRMS1 score index
Clinical parameter	Expression	Low	High^a	P
Mean tumor depth (mm)		3.60 (3.29)^b	2.42 (2.46)	0.040
	No	41	53
Ulceration	Yes	30	16	0.020
Marker
Cyclin D3	Low	42	57
	High	32	12	0.001
	Low	43	29
Cytoplasmic p-ERK	High	32	46	0.033
	Low	46	59	0.013
Nuclear p-Akt	High	26	12

^aHigh score index defined as ≥ 4
Low protein expression was defined as immunoreactivity in less than 5% (cyclin D3) [21]
in < 50% of the tumor cells (p-Akt) [25], or total lack of expression (p-ERK) [23]
^bSD

ISSN: 1471-2407