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Table 2 Relationship between cytoplasmic BRMS1 score index, ulceration, tumor thickness, cyclin D3 and activation of ERK1/2 and Akt

From: Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

   Cytoplasmic BRMS1 score index  
Clinical parameter Expression Low Higha P
   Mean tumor depth (mm)   3.60 (3.29)b 2.42 (2.46) 0.040
  No 41 53  
   Ulceration Yes 30 16 0.020
   Marker     
   Cyclin D3 Low 42 57  
  High 32 12 0.001
  Low 43 29  
   Cytoplasmic p-ERK High 32 46 0.033
  Low 46 59 0.013
   Nuclear p-Akt High 26 12  
  1. aHigh score index defined as ≥ 4
  2. Low protein expression was defined as immunoreactivity in less than 5% (cyclin D3) [21]
  3. in < 50% of the tumor cells (p-Akt) [25], or total lack of expression (p-ERK) [23]
  4. bSD