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Table 2 Association between XRCC1 Arg194Trp and Arg399Gln polymorphisms with objective response and overall survival

From: Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis

XRCC1 Objective response Overall survival
Arg194Trp Study Fixed effect Random effect Phet* Study Fixed effect Random effect Phet*
C/T vs. C/C 10 2.54[1.95,3.31] 2.54[1.95,3.32] 0.590     
T/T vs. C/C 10 2.06[1.39,3.06] 2.06[1.38,3.08] 0.888     
T/T+C/T vs. C/C 10 2.42[1.88,3.10] 2.41[1.87,3.10] 0.830     
XRCC1 Objective response Overall survival
Arg399Gln Study Fixed effect Random effect Phet* Study Fixed effect Random effect Phet*
G/A vs. G/G 9 0.67[0.50,0.90] 0.67[0.46,0.97] 0.159 8 1.23[1.06,1.44] 1.23[1.06,1.44] 0.557
A/A vs. G/G 9 0.43[0.25,0.73] 0.43[0.25,0.84] 0.965 8 1.41[1.19,1.67] 2.03[1.20,3.45] 0.000
A/A+G/A vs. G/G 10 0.63[0.49,0.83] 0.63[0.46,0.86] 0.206 3 1.18[0.93,1.50] 1.18[0.92,1.51] 0.329
Interaction Objective response Overall survival
  Study Fixed effect Random effect Phet* Study Fixed effect Random effect Phet*
c2 vs. c1 4 0.72[0.39,1.33] 0.73[0.39,1.38] 0.383     
c3 vs. c1 4 0.27[0.14,0.53] 0.28[0.14,0.57] 0.427     
c4 vs. c1 4 0.37[0.22,0.65] 0.38[0.21,0.67] 0.449     
  1. Combinations of XRCC1 Arg194Trp and XRCC1 Arg399Gln polymorphisms: c1, combination of 194 C/T + T/T and 399 G/G; c2, combination of 194 C/T + T/T and 399 G/A + A/A; c3: combination of 194 C/C and 399 G/G; c4, combination of 194 C/C and 399 G/A + A/A.
  2. *Phet: P values for the between-study heterogeneity.