Table 2 Association between XRCC1 Arg194Trp and Arg399Gln polymorphisms with objective response and overall survival

C/T vs. C/C

10

2.54[1.95,3.31]

2.54[1.95,3.32]

0.590

T/T vs. C/C

10

2.06[1.39,3.06]

2.06[1.38,3.08]

0.888

T/T+C/T vs. C/C

10

2.42[1.88,3.10]

2.41[1.87,3.10]

0.830

XRCC1

Objective response

Overall survival

Arg399Gln

Study

Fixed effect

Random effect

Phet*

Study

Fixed effect

Random effect

Phet*

G/A vs. G/G

9

0.67[0.50,0.90]

0.67[0.46,0.97]

0.159

8

1.23[1.06,1.44]

1.23[1.06,1.44]

0.557

A/A vs. G/G

9

0.43[0.25,0.73]

0.43[0.25,0.84]

0.965

8

1.41[1.19,1.67]

2.03[1.20,3.45]

0.000

A/A+G/A vs. G/G

10

0.63[0.49,0.83]

0.63[0.46,0.86]

0.206

3

1.18[0.93,1.50]

1.18[0.92,1.51]

0.329

Interaction

Objective response

Overall survival

Study

Fixed effect

Random effect

Phet*

Study

Fixed effect

Random effect

Phet*

c2 vs. c1

4

0.72[0.39,1.33]

0.73[0.39,1.38]

0.383

c3 vs. c1

4

0.27[0.14,0.53]

0.28[0.14,0.57]

0.427

c4 vs. c1

4

0.37[0.22,0.65]

0.38[0.21,0.67]

0.449