The TERT rs2736100 Polymorphism and Cancer Risk: A Meta-analysis Based on 25 Case-Control Studies

BMC Cancer

Table 2 Stratified analyses of the TERT rs2736100 polymorphism on cancer risk

Variables	GG versus TT		GT versus TT		Dominant model		Recessive model		Additive model
	OR(95%CI)	P ^a	OR(95%CI)	P ^a	OR(95%CI)	P ^a	OR(95%CI)	P ^a	OR(95%CI)	P ^a
Total	1.72(1.58-1.88)^b	0.002	1.38(1.29-1.47)^b	0.012	1.47(1.37-1.58)^b	0.001	1.37(1.31-1.43)	0.062	1.30(1.25-1.36)^b	0.004
Cancer type
Lung cancer	1.74(1.54-1.96)^b	0.008	1.34(1.23-1.46)^b	0.031	1.44(1.32-1.57)^b	0.009	1.39(1.32-1.47)	0.077	1.32(1.24-1.40)^b	0.009
Glioma	1.76(1.51-2.06)^b	0.017	1.47(1.36-1.60)	0.138	1.57(1.39-1.77)^b	0.040	1.34(1.24-1.44)	0.174	1.31(1.22-1.40)^b	0.044
Other cancer	1.46(1.13-1.89)	0.592	1.24(1.01-1.54)	0.522	1.30(1.06-1.59)	0.725	1.22(0.99-1.51)	0.245	1.19(1.05-1.34)	0.644
Source of control
Population based	1.80(1.56-2.07)^b	0.001	1.44(1.28-1.61)^b	0.004	1.53(1.36-1.73)^b	0.000	1.38(1.29-1.47)	0.069	1.32(1.24-1.42)^b	0.002
Hospital based	1.57(1.46-1.68)	0.949	1.29(1.22-1.37)	0.892	1.36(1.29-1.44)	0.963	1.33(1.25-1.41)	0.637	1.25(1.21-1.29)	0.960
Ethnicity
Asian	1.72(1.54-1.92)^b	0.013	1.32(1.22-1.43)^b	0.041	1.42(1.31-1.54)^b	0.013	1.40(1.33-1.47)	0.111	1.31(1.24-1.38)^b	0.013
European	1.72(1.48-2.01)^b	0.016	1.50(1.37-1.63)	0.266	1.58(1.46-1.72)	0.077	1.31(1.22-1.41)	0.160	1.30(1.21-1.39)^b	0.040

^a P value of Q-test for heterogeneity test
^bRandom-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used

ISSN: 1471-2407