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Table 2 Stratified analyses of the TERT rs2736100 polymorphism on cancer risk

From: The TERT rs2736100 Polymorphism and Cancer Risk: A Meta-analysis Based on 25 Case-Control Studies

Variables GG versus TT GT versus TT Dominant model Recessive model Additive model
  OR(95%CI) P a OR(95%CI) P a OR(95%CI) P a OR(95%CI) P a OR(95%CI) P a
Total 1.72(1.58-1.88)b 0.002 1.38(1.29-1.47)b 0.012 1.47(1.37-1.58)b 0.001 1.37(1.31-1.43) 0.062 1.30(1.25-1.36)b 0.004
Cancer type           
Lung cancer 1.74(1.54-1.96)b 0.008 1.34(1.23-1.46)b 0.031 1.44(1.32-1.57)b 0.009 1.39(1.32-1.47) 0.077 1.32(1.24-1.40)b 0.009
Glioma 1.76(1.51-2.06)b 0.017 1.47(1.36-1.60) 0.138 1.57(1.39-1.77)b 0.040 1.34(1.24-1.44) 0.174 1.31(1.22-1.40)b 0.044
Other cancer 1.46(1.13-1.89) 0.592 1.24(1.01-1.54) 0.522 1.30(1.06-1.59) 0.725 1.22(0.99-1.51) 0.245 1.19(1.05-1.34) 0.644
Source of control           
Population based 1.80(1.56-2.07)b 0.001 1.44(1.28-1.61)b 0.004 1.53(1.36-1.73)b 0.000 1.38(1.29-1.47) 0.069 1.32(1.24-1.42)b 0.002
Hospital based 1.57(1.46-1.68) 0.949 1.29(1.22-1.37) 0.892 1.36(1.29-1.44) 0.963 1.33(1.25-1.41) 0.637 1.25(1.21-1.29) 0.960
Ethnicity           
Asian 1.72(1.54-1.92)b 0.013 1.32(1.22-1.43)b 0.041 1.42(1.31-1.54)b 0.013 1.40(1.33-1.47) 0.111 1.31(1.24-1.38)b 0.013
European 1.72(1.48-2.01)b 0.016 1.50(1.37-1.63) 0.266 1.58(1.46-1.72) 0.077 1.31(1.22-1.41) 0.160 1.30(1.21-1.39)b 0.040
  1. a P value of Q-test for heterogeneity test
  2. bRandom-effects model was used when P value for heterogeneity test <0.05; otherwise, fix-effects model was used