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Table 4 Sensitivity and specificity within the ≥ 5%, ≥ 10%, ≥ 20% and ≥ 30% thresholds of the risk prediction models for the MMR germline mutation

From: Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries

Models and threshold Sensitivity Specificity
MMRpro   
≥ 5% 1.00 0.03
≥ 10% 0.96 0.08
≥ 20% 0.90 0.38
≥ 30% 0.87 0.52
MMRPredict   
≥ 5% 0.93 0.38
≥ 10% 0.90 0.33
≥ 20% 0.83 0.70
≥ 30% 0.80 0.75
Myriad   
≥ 5% 1.00 0
≥ 10% 0.94 0.31
≥ 20% 0.74 0.56
≥ 30% 0.10 0.92
PREMM   
≥ 5% 0.98 0.28
≥ 10% 0.90 0.54
≥ 20% 0.67 0.85
≥ 30% 0.67 0.85
Wijnen   
≥ 5% 1.00 0
≥ 10% 0.94 0.31
≥ 20% 0.74 0.56
≥ 30% 0.10 0.92