Table 1 TOX3 and LOC643714 mRNA expression compared with clinical and pathological characteristics

139

median (25% and 75%)

126

median (25% and 75%)

Age

< 50

59 (42%)

1.92 (0.9 - 4.5)

0.89

53 (42%)

3.1 E-4 (5.6 E-6 - 1.5 E-2)

0.07

≥ 50

80 (58%)

1.68 (1.1 - 4.0)

73 (58%)

1.7 E-3 (1.1 E-4 - 8.5 E-2)

Tumour size (mm)

≤ 20

42 (31%)

1.5 (1.0 - 4.8)

0.45

39 (31%)

6.4 E-4 (2.7 E-5 - 1.0 E-2)

0.26

> 20

95 (69%)

2.0 (1.0 - 4.5)

85 (69%)

1.1 E-3 (9.2 E-5 - 8.5 E-2)

unknown

2

2

Estrogen receptor

negative

44 (33%)

1.3 (0.4 - 3.3)

0.004

41 (34%)

9.3 E-6 (6.4 E-7 - 5.5 E-4)

< 0.001

positive

91 (67%)

2.1 (1.1 - 4.5)

81 (66%)

2.4 E-3 (4.6 E-4 - 9.8 E-2)

unknown

4

4

Progesterone receptor

negative

65 (49%)

1.4 (0.6 - 4.2)

0.005

59 (50%)

1.9 E-4 (1.4 E-6 - 3.1 E-3)

< 0.001

positive

67 (51%)

2.1 (1.3 - 4.3)

60 (50%)

3.3 E-3 (4.2 E-4 - 0.5)

unknown

7

7

ErbB2 status

negative

114 (83%)

1.8 (1.0 - 4.2)

0.81

107 (86%)

1.1 E-3 (6.6 E-5 - 7.7 E-2)

0.04

positive

24 (17%)

1.9 (0.8 - 5.0)

18 (14%)

2.7 E-4 (4.7 E-5 - 9.2 E-4)

unknown

1

1

Nodal status

negative

56 (44%)

1.3 (0.4 - 3.4)

< 0.001

53 (46%)

5.3 E-4 (1.9 E-6 - 2.3E-2)

0.04

positive

71 (56%)

2.2 (1.2 - 5.3)

62 (54%)

1.4 E-3 (2.0 E-4 - 5.7 E-2)

unknown

12

11

Ki67

Low

97 (71%)

2.1 (1.1 - 4.4)

0.026

87 (70%)

2.4 E-3 (2.2 E-4 - 9.0 E-2)

< 0.001

High

39 (29%)

1.2 (0.7 - 2.4)

37 (30%)

9.6 E-5 (1.9 E-6 - 9.0 E-4)

unknown

3

2

Histograde

1

12 (9%)

1.6 (0.8 - 3.5)

0.16

12 (9%)

1.1 E-3 (2.7 E-4 - 3.5 E-2)

0.01

2

78 (57%)

1.9 (1.1 - 4.4)

69 (56%)

3.5 E-3 (1.9 E-4 - 9.8 E-2)

3

47 (34%)

1.6 (0.5 - 4.2)

43 (35%)

2.3 E-4 (3.3 E-6 - 1.5 E-3)

unknown

2

2

Familial status ¹

BRCA2

26 (19%)

2.9 (0.8 - 5.1)

0.90

25 (20%)

6.7 E-4 (1.2 E-4 - 4.2 E-3)

0.40

Non-BRCA2

112 (81%)

1.6 (1.0 - 4.2)

100 (80%)

1.2 E-3 (6.3 E-5 - 6.4 E-2)

unknown

1

1

Subtype

Basal

20 (17%)

0.5 (0.1 – 1.3)

< 0.001

23 (21%)

3.1 E-6 (2.3 E-7 - 2.0 E-4)

< 0.001

ERBB2

15 (12%)

1.6 (1.2 - 5.0)

9 (8%)

9.7 E-4 (2.7 E-4 - 1.5 E-2)

Luminal A

43 (36%)

1.6 (1.1 - 3.1)

38 (35%)

8.9 E-3 (5.0 E-4 - 9.8 E-2)

Luminal B

30 (25%)

4.0 (1.6 - 5.4)

28 (26%)

1.2 E-3 (6.7 E-4 – 3.0 E-1)

Normal-like

12 (10%)

1.8 (1.2 - 4.4)

10 (9%)

5.8 E-4 (3.4 E-5 - 2.7 E-3)

Unclass/unknown

19

18

Histological type

Ductal

116 (86%)

2.1 (1.0 - 4.5)

0.12

105 (86%)

1.1 E-3 (9.2 E-5 - 5.2 E-2)

0.91

Lobular

11 (8%)

1.3 (1.3 - 2.2)

9 (7%)

6.2 E-4 (1.2 E-4 - 7.8 E-3)

other

8 (6%)

1.0 (0.6 - 1.5)

8 (7%)

9.8 E-5 (5.2 E-6 - 2.2 E-2)

unknown

4

4

Metastasis

negative

63 (50%)

1.6 (0.9 - 3.1)

0.18

63 (55%)

6.4 E-4 (6.3 E-6 - 1.9 E-2)

0.16

positive

63 (50%)

1.9 (1.1 - 4.9)

52 (45%)

1.6 E-3 (1.4 E-4 - 8.1 E-2)

unknown

13

11