| |
139
|
median (25% and 75%)
| |
126
|
median (25% and 75%)
| |
Age
|
|
< 50
|
59 (42%)
|
1.92 (0.9 - 4.5)
|
0.89
|
53 (42%)
|
3.1 E-4 (5.6 E-6 - 1.5 E-2)
|
0.07
|
|
≥ 50
|
80 (58%)
|
1.68 (1.1 - 4.0)
| |
73 (58%)
|
1.7 E-3 (1.1 E-4 - 8.5 E-2)
| |
Tumour size (mm)
|
|
≤ 20
|
42 (31%)
|
1.5 (1.0 - 4.8)
|
0.45
|
39 (31%)
|
6.4 E-4 (2.7 E-5 - 1.0 E-2)
|
0.26
|
|
> 20
|
95 (69%)
|
2.0 (1.0 - 4.5)
| |
85 (69%)
|
1.1 E-3 (9.2 E-5 - 8.5 E-2)
| |
|
unknown
|
2
| | |
2
| | |
Estrogen receptor
|
|
negative
|
44 (33%)
|
1.3 (0.4 - 3.3)
|
0.004
|
41 (34%)
|
9.3 E-6 (6.4 E-7 - 5.5 E-4)
|
< 0.001
|
|
positive
|
91 (67%)
|
2.1 (1.1 - 4.5)
| |
81 (66%)
|
2.4 E-3 (4.6 E-4 - 9.8 E-2)
| |
|
unknown
|
4
| | |
4
| | |
Progesterone receptor
|
|
negative
|
65 (49%)
|
1.4 (0.6 - 4.2)
|
0.005
|
59 (50%)
|
1.9 E-4 (1.4 E-6 - 3.1 E-3)
|
< 0.001
|
|
positive
|
67 (51%)
|
2.1 (1.3 - 4.3)
| |
60 (50%)
|
3.3 E-3 (4.2 E-4 - 0.5)
| |
|
unknown
|
7
| | |
7
| | |
ErbB2 status
|
|
negative
|
114 (83%)
|
1.8 (1.0 - 4.2)
|
0.81
|
107 (86%)
|
1.1 E-3 (6.6 E-5 - 7.7 E-2)
|
0.04
|
|
positive
|
24 (17%)
|
1.9 (0.8 - 5.0)
| |
18 (14%)
|
2.7 E-4 (4.7 E-5 - 9.2 E-4)
| |
|
unknown
|
1
| | |
1
| | |
Nodal status
|
|
negative
|
56 (44%)
|
1.3 (0.4 - 3.4)
|
< 0.001
|
53 (46%)
|
5.3 E-4 (1.9 E-6 - 2.3E-2)
|
0.04
|
|
positive
|
71 (56%)
|
2.2 (1.2 - 5.3)
| |
62 (54%)
|
1.4 E-3 (2.0 E-4 - 5.7 E-2)
| |
|
unknown
|
12
| | |
11
| | |
Ki67
|
|
Low
|
97 (71%)
|
2.1 (1.1 - 4.4)
|
0.026
|
87 (70%)
|
2.4 E-3 (2.2 E-4 - 9.0 E-2)
|
< 0.001
|
|
High
|
39 (29%)
|
1.2 (0.7 - 2.4)
| |
37 (30%)
|
9.6 E-5 (1.9 E-6 - 9.0 E-4)
| |
|
unknown
|
3
| | |
2
| | |
Histograde
|
|
1
|
12 (9%)
|
1.6 (0.8 - 3.5)
|
0.16
|
12 (9%)
|
1.1 E-3 (2.7 E-4 - 3.5 E-2)
|
0.01
|
|
2
|
78 (57%)
|
1.9 (1.1 - 4.4)
| |
69 (56%)
|
3.5 E-3 (1.9 E-4 - 9.8 E-2)
| |
|
3
|
47 (34%)
|
1.6 (0.5 - 4.2)
| |
43 (35%)
|
2.3 E-4 (3.3 E-6 - 1.5 E-3)
| |
|
unknown
|
2
| | |
2
| | |
Familial status
1
|
|
BRCA2
|
26 (19%)
|
2.9 (0.8 - 5.1)
|
0.90
|
25 (20%)
|
6.7 E-4 (1.2 E-4 - 4.2 E-3)
|
0.40
|
|
Non-BRCA2
|
112 (81%)
|
1.6 (1.0 - 4.2)
| |
100 (80%)
|
1.2 E-3 (6.3 E-5 - 6.4 E-2)
| |
|
unknown
|
1
| | |
1
| | |
Subtype
|
|
Basal
|
20 (17%)
|
0.5 (0.1 – 1.3)
|
< 0.001
|
23 (21%)
|
3.1 E-6 (2.3 E-7 - 2.0 E-4)
|
< 0.001
|
|
ERBB2
|
15 (12%)
|
1.6 (1.2 - 5.0)
| |
9 (8%)
|
9.7 E-4 (2.7 E-4 - 1.5 E-2)
| |
|
Luminal A
|
43 (36%)
|
1.6 (1.1 - 3.1)
| |
38 (35%)
|
8.9 E-3 (5.0 E-4 - 9.8 E-2)
| |
|
Luminal B
|
30 (25%)
|
4.0 (1.6 - 5.4)
| |
28 (26%)
|
1.2 E-3 (6.7 E-4 – 3.0 E-1)
| |
|
Normal-like
|
12 (10%)
|
1.8 (1.2 - 4.4)
| |
10 (9%)
|
5.8 E-4 (3.4 E-5 - 2.7 E-3)
| |
|
Unclass/unknown
|
19
| | |
18
| | |
Histological type
|
|
Ductal
|
116 (86%)
|
2.1 (1.0 - 4.5)
|
0.12
|
105 (86%)
|
1.1 E-3 (9.2 E-5 - 5.2 E-2)
|
0.91
|
|
Lobular
|
11 (8%)
|
1.3 (1.3 - 2.2)
| |
9 (7%)
|
6.2 E-4 (1.2 E-4 - 7.8 E-3)
| |
|
other
|
8 (6%)
|
1.0 (0.6 - 1.5)
| |
8 (7%)
|
9.8 E-5 (5.2 E-6 - 2.2 E-2)
| |
|
unknown
|
4
| | |
4
| | |
Metastasis
|
|
negative
|
63 (50%)
|
1.6 (0.9 - 3.1)
|
0.18
|
63 (55%)
|
6.4 E-4 (6.3 E-6 - 1.9 E-2)
|
0.16
|
|
positive
|
63 (50%)
|
1.9 (1.1 - 4.9)
| |
52 (45%)
|
1.6 E-3 (1.4 E-4 - 8.1 E-2)
| |
|
unknown
|
13
| | |
11
| | |