Table 1 Genes up regulated in SK-NEP-1 cells treated with YM155 compared with DMSO control group

1

TNF

Tumor necrosis factor

0.052

3.274

62.850

0.0085

2

FOXO1

Forkhead box O1

3.109

59.967

19.287

0.0091

3

IER3

Immediate early response 3

53.221

795.891

14.955

0.0093

4

PEA15

Phosphoprotein enriched in astrocytes 15

85.200

642.789

7.545

0.0105

5

CD5

CD5 molecule

0.079

0.584

7.405

0.0105

6

NDUFS3

NADH dehydrogenase (ubiquinone) Fe-S protein 3,

127.186

919.431

7.229

0.0106

7

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3

69.132

449.671

6.505

0.0109

8

NFKB1

nuclear factor of kappa gene enhancer in B-cells 1 

58.200

377.771

6.491

0.0109

9

CRYAB

Crystallin, alpha B

7.704

49.315

6.401

0.0109

10

DDIT3

DNA-damage-inducible transcript 3

134.710

768.681

5.706

0.0113

11

CRADD

CASP2 domain containing adaptor with death domain

10.127

56.007

5.531

0.0114

12

BNIP1

BCL2/adenovirus E1B 19 kDa interacting protein 1

89.770

475.609

5.298

0.0115

13

BBC3

BCL2 binding component 3

1.388

6.896

4.969

0.0118

14

NOX5

NADPH oxidase, EF-hand calcium binding domain 5 

0.213

1.057

4.953

0.0118

15

CASP7

Caspase 7, apoptosis-related cysteine peptidase

20.274

95.136

4.693

0.0120

16

PIM2

Pim-2 oncogene

29.093

118.888

4.087

0.0127

17

CEBPG

CCAAT/enhancer binding protein (C/EBP), gamma

11.867

47.745

4.023

0.0128

18

EDA

Ectodysplasin A

0.710

2.846

4.009

0.0128

19

SOCS2

Suppressor of cytokine signaling 2

0.258

1.018

3.953

0.0129

20

CDKN1A

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

124.431

479.383

3.853

0.0131

21

IL1A

Interleukin 1, alpha

146.968

423.629

2.882

0.0155

22

BIRC8

Baculoviral IAP repeat containing 8 

0.248

0.692

2.785

0.0159

23

SERPINB2

Serpin peptidase inhibitor, clade B member 2

0.136

0.362

2.659

0.0165

24

CASP9

Caspase 9, apoptosis-related cysteine peptidase

330.442

853.550

2.583

0.0169

25

LTB

Lymphotoxin beta (TNF superfamily, member 3)

0.052

0.134

2.580

0.0170

26

PMAIP1

Phorbol-12-myristate-13-acetate-induced protein 1 

258.441

642.950

2.488

0.0175

27

NUPR1

Nuclear protein, transcriptional regulator, 1

25.295

61.632

2.437

0.0179

28

BIRC3

Baculoviral IAP repeat containing 3

97.141

232.642

2.395

0.0183

29

DIABLO

IAP-binding mitochondrial protein 

178.419

417.832

2.342

0.0187

30

LTBR

Lymphotoxin beta receptor

120.546

280.744

2.329

0.0188

31

COL4A3

Collagen, type IV, alpha 3

5.993

12.916

2.155

0.0208

32

FOXO3

Forkhead box O3

34.671

71.488

2.062

0.0222