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Table 4 Joint effects of unfavorable genotypes in case patients and control subjects in Chinese

From: Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Risk group (no. unfavorable genotypes) Cases Controls OR (95% CI)*
Reference groupa (n = 0) 147 205 Reference
Low-risk reference group (n = 1) 96 83 1.51 (1.05- 2.17)
Medium-risk group (n = 2) 108 76 1.86 (1.30-2.67)
High-risk group b (n ≥3) 11 3 4.86 (1.33-17.71)
P for trend    <0.001
  1. *Adjusted for age, gender, smoking status, and pack-years.
  2. aReference group: GPX1 promoter: CC, MnSOD V16A: TT, SOD3 T58A: GG, and NOS1 3' UTR: CT+TT.
  3. bBecause the subject number in group ‘4’ was sparse (one control and three patients), the subjects with greater than three unfavourable genotypes were combined as the high-risk group.